Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0W3PY
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| Former ID |
DIB018753
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| Drug Name |
ACPT-I
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| Synonyms |
1-aminocyclopentane-1,3,4-tricarboxylic acid
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent | Investigative | [538884] | ||
| Structure |
|
Download2D MOL |
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| Formula |
C8H11NO6
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| InChI |
InChI=1S/C8H11NO6/c9-8(7(14)15)1-3(5(10)11)4(2-8)6(12)13/h3-4H,1-2,9H2,(H,10,11)(H,12,13)(H,14,15)/t3-,4+,8-
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| InChIKey |
FERIKTBTNCSGJS-KIGHRTHISA-N
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | mGlu6 receptor | Target Info | Agonist | [543751] | |
| Metabotropic glutamate receptor 4 | Target Info | Agonist | [534471] | ||
| Metabotropic glutamate receptor 8 | Target Info | Agonist | [525751] | ||
| PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
| Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | |||||
| Metabotropic glutamate receptor group III pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||||
| Metabotropic glutamate receptor group III pathway | |||||
| References | |||||
| Ref 525751 | Pharmacological characterization of the rat metabotropic glutamate receptor type 8a revealed strong similarities and slight differences with the type 4a receptor. Eur J Pharmacol. 2000 Apr 7;394(1):17-26. | ||||
| Ref 534471 | Synthesis and pharmacological characterization of aminocyclopentanetricarboxylic acids: new tools to discriminate between metabotropic glutamate receptor subtypes. J Med Chem. 1997 Sep 12;40(19):3119-29. | ||||
| Ref 543751 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 294). | ||||
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