Drug Information

Drug General Information
Drug ID
D0W1XX
Former ID
DIB021138
Drug Name
uridine triphosphate
Synonyms
5'-UTP; uridine 5'-triphosphate
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539086]
Structure
Download
2D MOL
Formula
C9H15N2O15P3
InChI
InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1
InChIKey
PGAVKCOVUIYSFO-XVFCMESISA-N
PubChem Compound ID
6133
PubChem Substance ID
3375, 584151, 831552, 833275, 833716, 841750, 855457, 7838933, 7891028, 7980869, 8027183, 8027189, 8143371, 8153844, 11335444, 11360683, 11364591, 11367153, 11369715, 11372791, 11374619, 11377877, 11461655, 11484245, 11488341, 11491411, 11492666, 11495511, 14720137, 14761469, 14932630, 17436071, 17436075, 24277146, 24277190, 24775910, 26706259, 26736753, 26737220, 26756678, 29225136, 47365080, 47662170, 47810645, 50061760, 53788170, 56312062, 56312125, 56312759, 56312760
Target and Pathway
Target(s) P2Y purinoceptor 2 Target Info Agonist [526232]
P2Y4 receptor Target Info Agonist [525757]
P2Y11 receptor Target Info Agonist [526628]
P2Y purinoceptor 6 Target Info Agonist [534141]
KEGG Pathway Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channelshsa04080:Neuroactive ligand-receptor interaction
NetPath Pathway IL5 Signaling Pathway
Reactome G alpha (q) signalling events
P2Y receptors
Surfactant metabolismR-HSA-416476:G alpha (q) signalling events
WikiPathways Nucleotide GPCRs
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signalingWP80:Nucleotide GPCRs
GPCR downstream signaling
References
Ref 539086(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1734).
Ref 525757ATP, an agonist at the rat P2Y(4) receptor, is an antagonist at the human P2Y(4) receptor. Mol Pharmacol. 2000 May;57(5):926-31.
Ref 526232Methanocarba modification of uracil and adenine nucleotides: high potency of Northern ring conformation at P2Y1, P2Y2, P2Y4, and P2Y11 but not P2Y6 receptors. J Med Chem. 2002 Jan 3;45(1):208-18.
Ref 526628Characterization of a Ca2+ response to both UTP and ATP at human P2Y11 receptors: evidence for agonist-specific signaling. Mol Pharmacol. 2003 Jun;63(6):1356-63.
Ref 534141Cloning, functional expression and tissue distribution of the human P2Y6 receptor. Biochem Biophys Res Commun. 1996 May 15;222(2):303-8.

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