Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0W0VD
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| Former ID |
DCL000494
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| Drug Name |
Beta-Lapachone
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| Synonyms |
ARQ 501; SL 11001; A-lapachone; LAPACHONE, BETA; AK-693/21096016; 2,2-dimethyl-3,4-dihydrobenzo[h]chromene-5,6-dione; 3,4-Dihydro-2,2-dimethyl-2H-naphtho(1,2-b)pyran-5,6-dione; 3,4-Dihydro-2,2-dimethyl-2H-naphtho[1,2-B]pyran-5,6-dione
|
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| Drug Type |
Small molecular drug
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| Indication | Solid tumours [ICD9: 140-199, 210-229; ICD10:C00-D48] | Phase 2 | [526407] | ||
| Company |
Roche
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| Structure |
|
Download2D MOL |
|||
| Formula |
C15H14O3
|
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| Canonical SMILES |
CC1(CCC2=C(O1)C3=CC=CC=C3C(=O)C2=O)C
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| InChI |
1S/C15H14O3/c1-15(2)8-7-11-13(17)12(16)9-5-3-4-6-10(9)14(11)18-15/h3-6H,7-8H2,1-2H3
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| InChIKey |
QZPQTZZNNJUOLS-UHFFFAOYSA-N
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| PubChem Compound ID | |||||
| PubChem Substance ID |
12553, 87198, 494711, 611544, 5669163, 8152448, 11111370, 11121371, 11121851, 11362440, 11365002, 11367564, 11370151, 11370152, 11373165, 11375726, 11414054, 15196477, 17405278, 24278512, 26753601, 29222999, 47365325, 47440387, 47589107, 47959891, 48110573, 48259373, 49996523, 50106535, 50106536, 50106537, 50106538, 53777823, 53788397, 57322036, 68530614, 79051855, 85087200, 85231108, 90340897, 91708861, 92304299, 92309722, 99300636, 99302154, 103178327, 103852913, 104304799, 117597465
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| Target and Pathway | |||||
| Target(s) | Toposisomerase-1 | Target Info | Modulator | [526407] | |
| NetPath Pathway | IL2 Signaling Pathway | ||||
| PANTHER Pathway | DNA replication | ||||
| Pathway Interaction Database | Caspase Cascade in Apoptosis | ||||
| WikiPathways | Integrated Pancreatic Cancer Pathway | ||||
| References | |||||
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