| Drug General Information |
| Drug ID |
D0W0PF
|
| Former ID |
DNC002907
|
| Drug Name |
2-Amino-6-Chloropyrazine
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C4H4ClN3
|
| Canonical SMILES |
C1=C(N=C(C=N1)Cl)N
|
| InChI |
1S/C4H4ClN3/c5-3-1-7-2-4(6)8-3/h1-2H,(H2,6,8)
|
| InChIKey |
JTPXVCKCLBROOJ-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
585611, 1591122, 3182670, 6466363, 7886609, 10238040, 15016587, 29198465, 29299526, 46393491, 46505223, 48436292, 49832465, 51245580, 56269577, 57339252, 81043034, 81054056, 87560944, 87617454, 92714828, 99225195, 99233364, 103464824, 103805734, 104405962, 117465833, 117529291, 117648046, 125275979, 125348205, 126577580, 126584796, 126613867, 126623828, 126655185, 126669836, 126735376, 128325878, 130425754, 131270013, 131383315, 131540170, 135074260, 135716837, 136025164, 136370304, 136907964, 136994144, 137017315
|
| Target and Pathway |
| Target(s) |
Cell division protein kinase 2 |
Target Info |
Inhibitor |
[1]
|
|---|
|
KEGG Pathway
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FoxO signaling pathway
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Cell cycle
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Oocyte meiosis
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p53 signaling pathway
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PI3K-Akt signaling pathway
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Progesterone-mediated oocyte maturation
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Hepatitis B
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Measles
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Herpes simplex infection
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Epstein-Barr virus infection
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Pathways in cancer
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Viral carcinogenesis
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Prostate cancer
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Small cell lung cancer
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NetPath Pathway
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TCR Signaling Pathway
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PANTHER Pathway
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p53 pathway
|
|
p53 pathway feedback loops 2
|
|
Pathway Interaction Database
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Regulation of nuclear SMAD2/3 signaling
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Signaling events mediated by PRL
|
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p73 transcription factor network
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E2F transcription factor network
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ATR signaling pathway
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mTOR signaling pathway
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IL2-mediated signaling events
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FoxO family signaling
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FOXM1 transcription factor network
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BARD1 signaling events
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p53 pathway
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Regulation of retinoblastoma protein
|
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Reactome
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G0 and Early G1
|
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Activation of ATR in response to replication stress
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Regulation of APC/C activators between G1/S and early anaphase
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SCF(Skp2)-mediated degradation of p27/p21
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Senescence-Associated Secretory Phenotype (SASP)
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DNA Damage/Telomere Stress Induced Senescence
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Processing of DNA double-strand break ends
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G2 Phase
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Orc1 removal from chromatin
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Cyclin E associated events during G1/S transition
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Cyclin A/B1 associated events during G2/M transition
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p53-Dependent G1 DNA Damage Response
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Cyclin A:Cdk2-associated events at S phase entry
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Meiotic recombination
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Factors involved in megakaryocyte development and platelet production
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WikiPathways
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DNA Damage Response
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ID signaling pathway
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DNA Replication
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G1 to S cell cycle control
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M/G1 Transition
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S Phase
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Meiotic Recombination
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Aryl Hydrocarbon Receptor
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ATM Signaling Pathway
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Retinoblastoma (RB) in Cancer
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Spinal Cord Injury
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Integrated Pancreatic Cancer Pathway
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Oncostatin M Signaling Pathway
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Prostate Cancer
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Signaling Pathways in Glioblastoma
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TSH signaling pathway
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Integrated Breast Cancer Pathway
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Integrated Cancer pathway
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Synthesis of DNA
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Regulation of DNA replication
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Mitotic G2-G2/M phases
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Mitotic G1-G1/S phases
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Factors involved in megakaryocyte development and platelet production
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Cell Cycle
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APC/C-mediated degradation of cell cycle proteins
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Cell Cycle Checkpoints
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miRNA Regulation of DNA Damage Response
|
| References |
| REF 1 | How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. |
|---|
