TTD | Drug: D0VR8J

Drug General Information
Drug ID	D0VR8J
Former ID	DIB020619
Drug Name	ONO-AP-324
Synonyms	ONO AP 324
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[541140]
Structure		Download 2D MOL
Formula	C28H25NO4
InChI	InChI=1S/C28H25NO4/c30-26(29-28(21-9-3-1-4-10-21)22-11-5-2-6-12-22)18-17-20-13-7-15-24-23(20)14-8-16-25(24)33-19-27(31)32/h1-16,28H,17-19H2,(H,29,30)(H,31,32)
InChIKey	YAPFKFDLARVWDB-UHFFFAOYSA-N
PubChem Compound ID	9867828
PubChem Substance ID	14832714, 24159331, 45290092, 79998611, 99431542, 129767938, 170503099, 178102446, 186020997, 226986334, 252154097, 252811533
Target and Pathway
Target(s)	Prostaglandin E2 receptor EP3 subtype	Target Info	Agonist	[534778]
KEGG Pathway	Calcium signaling pathway
	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	Regulation of lipolysis in adipocytes
	Pathways in cancer
NetPath Pathway	IL2 Signaling Pathway
Reactome	Prostanoid ligand receptors
Reactome	G alpha (i) signalling events
WikiPathways	Prostaglandin Synthesis and Regulation
	GPCRs, Class A Rhodopsin-like
	Small Ligand GPCRs
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 541140	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5821).
Ref 534778	Characterization of a prostanoid EP3-receptor in guinea-pig aorta: partial agonist action of the non-prostanoid ONO-AP-324. Br J Pharmacol. 1998 Nov;125(6):1288-96.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.

Drug Information