Drug Information

Drug General Information
Drug ID
D0VI1H
Former ID
DNC012909
Drug Name
COLCHINOL
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527777]
Structure
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2D MOL

3D MOL
Formula
C18H21NO4
Canonical SMILES
COC1=C(C(=C2C(=C1)CCC(C3=C2C=CC(=C3)O)N)OC)OC
InChI
1S/C18H21NO4/c1-21-15-8-10-4-7-14(19)13-9-11(20)5-6-12(13)16(10)18(23-3)17(15)22-2/h5-6,8-9,14,20H,4,7,19H2,1-3H3/t14-/m0/s1
InChIKey
HSDSUBIABLFGDX-AWEZNQCLSA-N
PubChem Compound ID
164612
Target and Pathway
Target(s) Tubulin beta Target Info Inhibitor [527777]
Tubulin Target Info Inhibitor [527777]
KEGG Pathway Phagosome
Gap junction
Pathogenic Escherichia coli infection
NetPath Pathway FSH Signaling Pathway
TCR Signaling Pathway
EGFR1 Signaling Pathway
PANTHER Pathway Cytoskeletal regulation by Rho GTPase
Huntington disease
Reactome Regulation of PLK1 Activity at G2/M Transition
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization?from the centrosome
Anchoring of the basal body to the plasma membrane
WikiPathways Parkin-Ubiquitin Proteasomal System pathway
Pathogenic Escherichia coli infection
Mitotic G2-G2/M phases
References
Ref 527777Bioorg Med Chem Lett. 2005 Dec 1;15(23):5154-9. Epub 2005 Sep 28.Synthesis and structure-activity relationships of 1,2,4-triazoles as a novel class of potent tubulin polymerization inhibitors.
Ref 527777Bioorg Med Chem Lett. 2005 Dec 1;15(23):5154-9. Epub 2005 Sep 28.Synthesis and structure-activity relationships of 1,2,4-triazoles as a novel class of potent tubulin polymerization inhibitors.

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