Drug Information

Drug General Information
Drug ID
D0V9MI
Former ID
DNC005487
Drug Name
BAY-60-7550
Drug Type
Small molecular drug
Indication Discovery agent Investigative [468210]
Structure
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2D MOL

3D MOL
Formula
C27H32N4O4
InChI
InChI=1S/C27H32N4O4/c1-17-25-27(33)29-24(16-20-13-14-22(34-3)23(15-20)35-4)30-31(25)26(28-17)21(18(2)32)12-8-11-19-9-6-5-7-10-19/h5-7,9-10,13-15,18,21,32H,8,11-12,16H2,1-4H3,(H,29,30,33)/t18-,21+/m1/s1
InChIKey
MYTWFJKBZGMYCS-NQIIRXRSSA-N
PubChem Compound ID
25273570
PubChem Substance ID
58108288, 103463380, 104052288, 134342692, 135653426, 136920287, 140169512, 142288760, 143496927, 152236881, 152258618, 160647453, 160874309, 162255251, 163123670, 163831418, 164836119, 172918193, 175427602, 178101839, 185998789, 198988390, 208013167, 228360107, 244843597, 252477802
Target and Pathway
Target(s) CGMP-dependent3',5'-cyclic phosphodiesterase Target Info Inhibitor [527549]
KEGG Pathway Purine metabolism
cGMP-PKG signaling pathway
Morphine addiction
NetPath Pathway TSH Signaling Pathway
Reactome cGMP effects
G alpha (s) signalling events
References
Ref 468210(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5147).
Ref 527549J Med Chem. 2005 May 19;48(10):3449-62.The next generation of phosphodiesterase inhibitors: structural clues to ligand and substrate selectivity of phosphodiesterases.

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