Drug General Information
Drug ID
D0V6NX
Former ID
DIB005822
Drug Name
P2X7 antagonists
Synonyms
P2X7 antagonists (pain); P2X7 antagonists (pain), GlaxoSmithKline
Indication Pain [ICD9: 338, 356.0, 356.8,780; ICD10:G64, G90.0, R52, G89] Investigative [552150]
Company
GlaxoSmithKline plc
Structure
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2D MOL

3D MOL

Canonical SMILES
N1([C@@H](CNC1=O)C(=O)NCc1c(cc(cc1)Cl)Cl)C
Target and Pathway
Target(s) P2X purinoceptor 7 Target Info Antagonist [543850]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Reactome The NLRP3 inflammasome
WikiPathways Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
References
Ref 552150Paradoxical P2X7. Baas, T. SciBX 5(20).
Ref 543850(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 484).

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