Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0V6DJ
|
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| Former ID |
DIB018659
|
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| Drug Name |
5-methylurapidil
|
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| Synonyms |
5 methylurapidil; 5-methyl-urapidil
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Investigative | [468088] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C21H31N5O3
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| InChI |
InChI=1S/C21H31N5O3/c1-16-19(23(2)21(28)24(3)20(16)27)22-10-7-11-25-12-14-26(15-13-25)17-8-5-6-9-18(17)29-4/h5-6,8-9,22H,7,10-15H2,1-4H3
|
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| InChIKey |
HIHZDNKKIUQQSC-UHFFFAOYSA-N
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| PubChem Compound ID | |||||
| PubChem Substance ID |
5416505, 7978603, 8153469, 11111937, 14854814, 17405829, 26753682, 29224677, 46500368, 47440498, 47959989, 48334744, 50064709, 50107230, 50107231, 53778381, 57322879, 78567119, 85208927, 85231281, 90340943, 92098503, 92303222, 103146517, 103299542, 103941453, 104309821, 117588404, 121362076, 124750374, 124800049, 124881772, 124881773, 128064993, 135072905, 135649841, 162841096, 163565229, 178126959, 179150352, 198946634, 232104651
|
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| Target and Pathway | |||||
| Target(s) | Alpha-2C adrenergic receptor | Target Info | Antagonist | [526042] | |
| Alpha-1B adrenergic receptor | Target Info | Antagonist | [526102] | ||
| NetPath Pathway | IL2 Signaling Pathway | ||||
| Pathway Interaction Database | LPA receptor mediated events | ||||
| Reactome | Adrenoceptors | ||||
| Adrenaline signalling through Alpha-2 adrenergic receptor | |||||
| Adrenaline,noradrenaline inhibits insulin secretion | |||||
| G alpha (i) signalling events | |||||
| G alpha (z) signalling events | |||||
| Surfactant metabolismR-HSA-390696:Adrenoceptors | |||||
| G alpha (q) signalling events | |||||
| G alpha (12/13) signalling events | |||||
| WikiPathways | Monoamine GPCRs | ||||
| GPCRs, Class A Rhodopsin-like | |||||
| Platelet Aggregation (Plug Formation) | |||||
| Integration of energy metabolism | |||||
| GPCR ligand binding | |||||
| GPCR downstream signalingWP58:Monoamine GPCRs | |||||
| Calcium Regulation in the Cardiac Cell | |||||
| Vitamin D Receptor Pathway | |||||
| Gastrin-CREB signalling pathway via PKC and MAPK | |||||
| GPCR downstream signaling | |||||
| AMPK Signaling | |||||
| References | |||||
| Ref 526042 | Phe-308 and Phe-312 in transmembrane domain 7 are major sites of alpha 1-adrenergic receptor antagonist binding. Imidazoline agonists bind like antagonists. J Biol Chem. 2001 Jul 6;276(27):25366-71. Epub 2001 Apr 30. | ||||
| Ref 526102 | Affinity of serotonin receptor antagonists and agonists to recombinant and native alpha1-adrenoceptor subtypes. Jpn J Pharmacol. 2001 Jun;86(2):189-95. | ||||
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