| Drug General Information |
| Drug ID |
D0V5SQ
|
| Former ID |
DIB020975
|
| Drug Name |
spiramide
|
| Synonyms |
AMI-193; R-5808
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
|
| Formula |
C22H26FN3O2
|
| InChI |
InChI=1S/C22H26FN3O2/c23-18-7-9-20(10-8-18)28-16-4-13-25-14-11-22(12-15-25)21(27)24-17-26(22)19-5-2-1-3-6-19/h1-3,5-10H,4,11-17H2,(H,24,27)
|
| InChIKey |
FJUKDAZEABGEIH-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
6524684, 8191916, 11113547, 14804795, 26751754, 26751755, 43124793, 47288884, 47808500, 47808501, 47883138, 56311623, 57316755, 77160247, 85229950, 85788762, 91746247, 103283755, 103821221, 103975696, 104341470, 117511070, 124886921, 124886922, 124886923, 127857576, 135025008, 135610762, 135649934, 135698131, 136352574, 137147741, 142256309, 144204465, 162223889, 163132611, 170466454, 179236208, 198970375, 228249517, 241181723, 241377377, 249934490
|
| Target and Pathway |
| Target(s) |
5-hydroxytryptamine 2B receptor |
Target Info |
Antagonist |
[2]
|
|---|
| 5-hydroxytryptamine 2A receptor |
Target Info |
Antagonist |
[2]
|
| 5-hydroxytryptamine 2C receptor |
Target Info |
Antagonist |
[2]
|
|
KEGG Pathway
|
Calcium signaling pathway
|
|
Neuroactive ligand-receptor interaction
|
|
Gap junction
|
|
Serotonergic synapse
|
|
Inflammatory mediator regulation of TRP channelshsa04020:Calcium signaling pathway
|
|
Inflammatory mediator regulation of TRP channels
|
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PANTHER Pathway
|
5HT2 type receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathway
|
|
Reactome
|
Serotonin receptors
|
|
G alpha (q) signalling eventsR-HSA-390666:Serotonin receptors
|
|
G alpha (q) signalling events
|
|
WikiPathways
|
Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
|
|
Monoamine GPCRs
|
|
GPCRs, Class A Rhodopsin-like
|
|
Gastrin-CREB signalling pathway via PKC and MAPK
|
|
GPCR ligand binding
|
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GPCR downstream signalingWP733:Serotonin Receptor 2 and STAT3 Signaling
|
|
SIDS Susceptibility Pathways
|
|
GPCR downstream signaling
|
|
GPCRs, OtherWP732:Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
|
| References |
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 175). |
|---|
| REF 2 | Pharmacological characterisation of the agonist radioligand binding site of 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors. Naunyn Schmiedebergs Arch Pharmacol. 2004 Aug;370(2):114-23. Epub 2004 Jul 30. |
|---|
