Drug General Information
Drug ID
D0V5NZ
Former ID
DNC008568
Drug Name
5'-(N-ethyl-N-isopropyl)amiloride
Drug Type
Small molecular drug
Indication Discovery agent Investigative [467523]
Structure
Download
2D MOL

3D MOL

Formula
C11H18ClN7O
InChI
InChI=1S/C11H18ClN7O/c1-4-19(5(2)3)9-7(12)16-6(8(13)17-9)10(20)18-11(14)15/h5H,4H2,1-3H3,(H2,13,17)(H4,14,15,18,20)
InChIKey
QDERNBXNXJCIQK-UHFFFAOYSA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Sodium/hydrogen exchanger 1 Target Info Inhibitor [528830]
KEGG Pathway cAMP signaling pathway
Cardiac muscle contraction
Adrenergic signaling in cardiomyocytes
Regulation of actin cytoskeleton
Thyroid hormone signaling pathway
Salivary secretion
Gastric acid secretion
Pancreatic secretion
Bile secretion
Proteoglycans in cancer
Pathway Interaction Database Endothelins
RhoA signaling pathway
ErbB1 downstream signaling
Signaling mediated by p38-alpha and p38-beta
Reactome Hyaluronan uptake and degradation
WikiPathways Regulation of Actin Cytoskeleton
G Protein Signaling Pathways
Glycosaminoglycan metabolism
Osteoclast Signaling
References
Ref 467523(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4186).
Ref 528830J Biol Chem. 2007 Jul 6;282(27):19716-27. Epub 2007 May 10.NHE1 inhibition by amiloride- and benzoylguanidine-type compounds. Inhibitor binding loci deduced from chimeras of NHE1 homologues with endogenous differences in inhibitor sensitivity.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.