Drug Information

Drug General Information
Drug ID
D0V3WS
Former ID
DNC013750
Drug Name
(S,R)-antioquine hydrochloride
Drug Type
Small molecular drug
Indication Discovery agent Investigative [551356]
Structure
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2D MOL

3D MOL
Formula
C37H41ClN2O6
Canonical SMILES
CN1CCC2=CC(=C3C=C2C1CC4=CC(=C(C=C4)O)C5=C(C=CC(=C5)CC6C<br />7=C(O3)C(=C(C=C7CCN6C)OC)O)OC)OC.Cl
InChI
1S/C37H40N2O6.ClH/c1-38-12-10-23-18-32(43-4)33-20-25(23)28(38)16-21-6-8-30(40)26(14-21)27-15-22(7-9-31(27)42-3)17-29-35-24(11-13-39(29)2)19-34(44-5)36(41)37(35)45-33;/h6-9,14-15,18-20,28-29,40-41H,10-13,16-17H2,1-5H3;1H/t28-,29+;/m1./s1
InChIKey
XMYUKGNJCHUIHP-XZVFQGBBSA-N
PubChem Compound ID
44584687
Target and Pathway
Target(s) D(2) dopamine receptor Target Info Inhibitor [551356]
KEGG Pathway Rap1 signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Alcoholism
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Dopamine receptor mediated signaling pathway
Nicotine pharmacodynamics pathway
Reactome Dopamine receptors
G alpha (i) signalling events
WikiPathways Hypothetical Network for Drug Addiction
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Genes and (Common) Pathways Underlying Drug Addiction
GPCR ligand binding
GPCR downstream signaling
Nicotine Activity on Dopaminergic Neurons
References
Ref 551356Displacement activity of bisbenzylisoquinoline alkaloids at striatal 3H-SCH 23390 and 3H-raclopride binding sites. J Nat Prod. 1992 Sep;55(9):1281-6.
Ref 551356Displacement activity of bisbenzylisoquinoline alkaloids at striatal 3H-SCH 23390 and 3H-raclopride binding sites. J Nat Prod. 1992 Sep;55(9):1281-6.

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