Drug Information

Drug General Information
Drug ID
D0V3OY
Former ID
DIB018428
Drug Name
[3H]U69593
Synonyms
[3H]-U69593
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539025]
Structure
Download
2D MOL

3D MOL
Formula
C22H32N2O2
InChI
InChI=1S/C22H32N2O2/c1-23(21(25)16-18-8-3-2-4-9-18)19-10-12-22(11-7-15-26-22)17-20(19)24-13-5-6-14-24/h2-4,8-9,19-20H,5-7,10-17H2,1H3/t19-,20-,22-/m0/s1
InChIKey
PGZRDDYTKFZSFR-ONTIZHBOSA-N
PubChem Compound ID
105104
PubChem Substance ID
841864, 7980860, 10233764, 26756545, 44434631, 48032743, 49689203, 50066063, 50093889, 53787917, 57338019, 76304920, 103177815, 103841744, 104373646, 117567761, 124892412, 128914721, 134349034, 135062519, 135651213, 135651293, 136946583, 142250937, 144205579, 144239943, 162224354, 163426066, 170466866, 172914645, 198966748, 227014322, 252451182
Target and Pathway
Target(s) Kappa-type opioid receptor Target Info Agonist [533399]
KEGG Pathway Neuroactive ligand-receptor interaction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Opioid prodynorphin pathway
Reactome Peptide ligand-binding receptors
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 539025(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1656).
Ref 533399[3H]U-69593 a highly selective ligand for the opioid kappa receptor. Eur J Pharmacol. 1985 Feb 26;109(2):281-4.

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