Drug Information
Drug General Information | |||||
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Drug ID |
D0V3HG
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Former ID |
DNC000488
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Drug Name |
CV-6504
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Drug Type |
Small molecular drug
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Indication | Discovery agent | Discontinued in Phase 2 | [545370] | ||
Structure |
Download2D MOL |
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Formula |
C15H15NO2
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Canonical SMILES |
CC1=C(C(=O)C(=C(C1=O)C)CC2=CN=CC=C2)C
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InChI |
1S/C15H15NO2/c1-9-10(2)15(18)13(11(3)14(9)17)7-12-5-4-6-16-8-12/h4-6,8H,7H2,1-3H3
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InChIKey |
IPGAFOVEIIWXFR-UHFFFAOYSA-N
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CAS Number |
CAS 117574-40-0
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PubChem Compound ID | |||||
PubChem Substance ID | |||||
Target and Pathway | |||||
Target(s) | Arachidonate 5-lipoxygenase | Target Info | Inhibitor | [535071], [537655] | |
NetPath Pathway | IL4 Signaling Pathway | ||||
PathWhiz Pathway | Arachidonic Acid Metabolism | ||||
References | |||||
Ref 535071 | A phase II study of the 5-lipoxygenase inhibitor, CV6504, in advanced pancreatic cancer: correlation of clinical data with pharmacokinetic and pharmacodynamic endpoints. Ann Oncol. 2000 Sep;11(9):1165-70. | ||||
Ref 537655 | Involvement of thromboxane A2, leukotrienes and free radicals in puromycin nephrosis in rats. Kidney Int. 1991 May;39(5):920-9. |
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