Drug Information

Drug General Information
Drug ID
D0U9YH
Former ID
DCL000022
Drug Name
GSK 659032
Drug Type
Small molecular drug
Indication Cardiovascular disorder [ICD10:I00-I99] Phase 1 [547694]
Company
Human Genome Sci
Structure
Download
2D MOL

3D MOL
Formula
C40H38F5N3O3S
Canonical SMILES
COCCN1CCC(CC1)N(CC2=CC=C(C=C2)C3=CC=C(C=C3)C(F)(F)F)C(=<br />O)CN4C5=CC=CC=C5C(=O)C=C4SCC6=C(C(=CC=C6)F)F
InChI
1S/C40H38F5N3O3S/c1-51-22-21-46-19-17-32(18-20-46)47(24-27-9-11-28(12-10-27)29-13-15-31(16-14-29)40(43,44)45)37(50)25-48-35-8-3-2-6-33(35)36(49)23-38(48)52-26-30-5-4-7-34(41)39(30)42/h2-16,23,32H,17-22,24-26H2,1H3
InChIKey
NNBGCSGCRSCFEA-UHFFFAOYSA-N
PubChem Compound ID
9918381
Target and Pathway
Target(s) Lipoprotein-associated phospholipase A2 Target Info Inhibitor [537512]
KEGG Pathway Ether lipid metabolism
Metabolic pathways
Biosynthesis of antibiotics
Pathway Interaction Database Lissencephaly gene (LIS1) in neuronal migration and development
WikiPathways IL1 and megakaryotyces in obesity
Synthesis, Secretion, and Deacylation of Ghrelin
References
Ref 547694Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800018454)
Ref 537512Phospholipase A2 inhibitors. Curr Opin Lipidol. 2009 Aug;20(4):327-32.

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