Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0U8UV
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| Former ID |
DAP000333
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| Drug Name |
Dimenhydrinate
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| Synonyms |
Dramamine (TN); Gravamin (TN); Gravol (TN); Vertirosan (TN); Dimenhydrinate (JP15/USP/INN); 2-(diphenylmethoxy)-N,N-dimethylethanaminium 8-chloro-1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydropurin-7-ide; 2-benzhydryloxyethyl(dimethyl)azanium; 8-chloro-1,3-dimethyl-2-oxopurin-6-olate; 8-chloro-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione-2-(diphenylmethoxy)-N,N-dimethylethanamine (1:1)
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| Drug Type |
Small molecular drug
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| Indication | Nausea; Vomiting [ICD9: 787, 787.0; ICD10:R11] | Approved | [538185] | ||
| Therapeutic Class |
Antiemetics
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| Company |
Carter-Horner Corp.
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| Structure |
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Download2D MOL |
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| Formula |
C24H28ClN5O3
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| Canonical SMILES |
CN1C(=C2C(=NC(=N2)Cl)N(C1=O)C)[O-].C[NH+](C)CCOC(C1=CC=<br />CC=C1)C2=CC=CC=C2
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| InChI |
1S/C17H21NO.C7H7ClN4O2/c1-18(2)13-14-19-17(15-9-5-3-6-10-15)16-11-7-4-8-12-16;1-11-4-3(9-6(8)10-4)5(13)12(2)7(11)14/h3-12,17H,13-14H2,1-2H3;13H,1-2H3
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| InChIKey |
KKRAMGIVRBZVCD-UHFFFAOYSA-N
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| CAS Number |
CAS 523-87-5
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | Histamine H1 receptor | Target Info | Antagonist | [535364], [536878] | |
| PANTHER Pathway | Histamine H1 receptor mediated signaling pathway | ||||
| References | |||||
| Ref 535364 | Mechanisms and abuse liability of the anti-histamine dimenhydrinate. Neurosci Biobehav Rev. 2002 Jan;26(1):61-7. | ||||
| Ref 536878 | Histamine 1 receptor antagonist in symptomatic treatment of renal colic accompanied by nausea: two birds with one stone? Urology. 2009 Jan;73(1):32-6. Epub 2008 Oct 11. | ||||
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