Drug General Information
Drug ID	D0U6QM
Former ID	DNC013089
Drug Name	1-(4-iodobenzyl)-1H-imidazole
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[531072]
Structure		Download 2D MOL 3D MOL
Formula	C10H9IN2
Canonical SMILES	C1=CC(=CC=C1CN2C=CN=C2)I
InChI	1S/C10H9IN2/c11-10-3-1-9(2-4-10)7-13-6-5-12-8-13/h1-6,8H,7H2
InChIKey	WZKZRSOWLZKJCL-UHFFFAOYSA-N
PubChem Compound ID	15984072
Target and Pathway
Target(s)	17 alpha-hydroxylase-C17, 20-lyase	Target Info	Inhibitor	[531072]
BioCyc Pathway	Superpathway of steroid hormone biosynthesis
	Glucocorticoid biosynthesis
	Androgen biosynthesis
KEGG Pathway	Steroid hormone biosynthesis
	Metabolic pathways
	Ovarian steroidogenesis
	Prolactin signaling pathway
PathWhiz Pathway	Androgen and Estrogen Metabolism
	Steroidogenesis
Reactome	Androgen biosynthesis
	Glucocorticoid biosynthesis
	Endogenous sterols
WikiPathways	Metapathway biotransformation
	Steroid Biosynthesis
	Oxidation by Cytochrome P450
	Metabolism of steroid hormones and vitamin D
	Glucocorticoid & Mineralcorticoid Metabolism
	Prostate Cancer
	Phase 1 - Functionalization of compounds
References
Ref 531072	Bioorg Med Chem Lett. 2010 Sep 1;20(17):5345-8. Epub 2010 Mar 3.Synthesis and biochemical evaluation of a range of (4-substituted phenyl)sulfonate derivatives of 4-hydroxybenzyl imidazole-based compounds as potent inhibitors of 17alpha-hydroxylase/17,20-lyase (P45017alpha) derived from rat testicular microsomes.
Ref 531072	Bioorg Med Chem Lett. 2010 Sep 1;20(17):5345-8. Epub 2010 Mar 3.Synthesis and biochemical evaluation of a range of (4-substituted phenyl)sulfonate derivatives of 4-hydroxybenzyl imidazole-based compounds as potent inhibitors of 17alpha-hydroxylase/17,20-lyase (P45017alpha) derived from rat testicular microsomes.

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