Drug Information
Drug General Information | |||||
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Drug ID |
D0U6FT
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Former ID |
DIB011656
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Drug Name |
GSI-136
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Synonyms |
WAY-179642; WAY-208983; WAY-GSI-A; WAY-GSI-B; Gamma-secretase inhibitors (oral, Alzheimer's disease), Wyeth
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Drug Type |
Small molecular drug
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Indication | Alzheimer disease [ICD9: 331; ICD10:G30] | Phase 1 | [522382] | ||
Company |
Wyeth
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Structure |
Download2D MOL |
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Formula |
C11H18ClNO3S2
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Canonical SMILES |
c1(ccc(s1)Cl)S(=O)(=O)N[C@@H]([C@@H](CC(F)(F)F)C)CO
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PubChem Compound ID | |||||
Target and Pathway | |||||
Target(s) | Gamma-secretase | Target Info | Modulator | [1572591] | |
KEGG Pathway | Notch signaling pathway | ||||
Alzheimer's disease | |||||
Reactome | Nuclear signaling by ERBB4 | ||||
Regulated proteolysis of p75NTR | |||||
NRIF signals cell death from the nucleus | |||||
Activated NOTCH1 Transmits Signal to the Nucleus | |||||
Constitutive Signaling by NOTCH1 PEST Domain Mutants | |||||
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | |||||
NOTCH2 Activation and Transmission of Signal to the Nucleus | |||||
EPH-ephrin mediated repulsion of cells | |||||
References |
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