Drug Information

Drug General Information
Drug ID
D0U1XJ
Former ID
DNC004362
Drug Name
HBR-985
Drug Type
Small molecular drug
Indication Discovery agent Investigative [535148]
Structure
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2D MOL

3D MOL
Formula
C18H20ClN3O5S
Canonical SMILES
CNC(=O)NS(=O)(=O)C1=CC=C(C=C1)CCNC(=O)C2=C(C=CC(=C2)Cl)<br />OC
InChI
1S/C18H20ClN3O5S/c1-20-18(24)22-28(25,26)14-6-3-12(4-7-14)9-10-21-17(23)15-11-13(19)5-8-16(15)27-2/h3-8,11H,9-10H2,1-2H3,(H,21,23)(H2,20,22,24)
InChIKey
RXOBKRPNVDTZQF-UHFFFAOYSA-N
PubChem Compound ID
219108
Target and Pathway
Target(s) Sulfonylurea receptor 1 Target Info Inhibitor [535148]
ATP-sensitive inward rectifier potassium channel 11 Target Info Inhibitor [535148]
KEGG Pathway ABC transporters
Insulin secretion
Type II diabetes mellitushsa04911:Insulin secretion
Type II diabetes mellitus
Pathway Interaction Database FOXA2 and FOXA3 transcription factor networkshnf3bpathway:FOXA2 and FOXA3 transcription factor networks
PathWhiz Pathway Muscle/Heart Contraction
Pancreas FunctionPW000564:Muscle/Heart Contraction
Reactome ABC-family proteins mediated transport
Regulation of insulin secretionR-HSA-382556:ABC-family proteins mediated transport
Regulation of insulin secretion
WikiPathways Potassium Channels
Integration of energy metabolismWP2669:Potassium Channels
Integration of energy metabolism
Type II diabetes mellitus
References
Ref 535148Cardioselective K(ATP) channel blockers derived from a new series of m-anisamidoethylbenzenesulfonylthioureas. J Med Chem. 2001 Mar 29;44(7):1085-98.
Ref 535148Cardioselective K(ATP) channel blockers derived from a new series of m-anisamidoethylbenzenesulfonylthioureas. J Med Chem. 2001 Mar 29;44(7):1085-98.

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