Drug Information

Drug General Information
Drug ID
D0U0VU
Former ID
DNC004927
Drug Name
SILODOSIN
Drug Type
Small molecular drug
Indication Benign prostatic hyperplasia [ICD9: 600; ICD10:N40] Approved [468101], [529941], [530665]
Structure
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2D MOL

3D MOL
Formula
C25H32F3N3O4
InChI
InChI=1S/C25H32F3N3O4/c1-17(30-8-12-34-21-5-2-3-6-22(21)35-16-25(26,27)28)13-18-14-19-7-10-31(9-4-11-32)23(19)20(15-18)24(29)33/h2-3,5-6,14-15,17,30,32H,4,7-13,16H2,1H3,(H2,29,33)/t17-/m1/s1
InChIKey
PNCPYILNMDWPEY-QGZVFWFLSA-N
CAS Number
CAS 160970-54-7
PubChem Compound ID
5312125
PubChem Substance ID
7849027, 7979683, 11056891, 12014894, 14810706, 14835413, 39341745, 57359519, 80176928, 92098546, 99299508, 103194366, 104046714, 109693099, 114157936, 126623000, 126665711, 128939931, 131300819, 134339064, 134340151, 134342132, 135252710, 135368407, 135650458, 135916576, 137248544, 142093997, 152258092, 152344280, 160646931, 162011672, 162172235, 162223757, 163884568, 164765008, 164777753, 172085148, 174527805, 175266679, 175427058, 175612190, 179150028, 184816547, 187071911, 198991703, 202821102, 211536181, 223392962, 223484371
SuperDrug ATC ID
G04CA04
Target and Pathway
Target(s) Alpha-1A adrenergic receptor Target Info Inhibitor [527393]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
AMPK signaling pathway
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Salivary secretion
PANTHER Pathway Alpha adrenergic receptor signaling pathway
Reactome Adrenoceptors
G alpha (q) signalling events
G alpha (12/13) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Endothelin Pathways
GPCR ligand binding
GPCR downstream signaling
AMPK Signaling
References
Ref 468101(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 493).
Ref 5299412008 FDA drug approvals. Nat Rev Drug Discov. 2009 Feb;8(2):93-6.
Ref 530665Silodosin: a selective alpha1A-adrenergic receptor antagonist for the treatment of benign prostatic hyperplasia. Clin Ther. 2009 Nov;31(11):2489-502.
Ref 527393Bioorg Med Chem Lett. 2005 Feb 1;15(3):657-64.Pharmacophore identification of alpha(1A)-adrenoceptor antagonists.

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