Drug Information

Drug General Information
Drug ID
D0U0VH
Former ID
DIB021103
Drug Name
U92016A
Synonyms
U-92,016-A; U-92016A
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540009]
Structure
Download
2D MOL
Formula
C19H25N3
InChI
InChI=1S/C19H25N3/c1-3-9-22(10-4-2)16-7-5-14-6-8-19-18(17(14)12-16)11-15(13-20)21-19/h6,8,11,16,21H,3-5,7,9-10,12H2,1-2H3/t16-/m1/s1
InChIKey
WDDZPZKGLZNGEH-MRXNPFEDSA-N
PubChem Compound ID
9904242
PubChem Substance ID
14873556, 24186092, 45975911, 77861999, 103267035, 103944820, 135651294, 137010534, 162224355, 232579208
Target and Pathway
Target(s) 5-hydroxytryptamine 1A receptor Target Info Agonist [533822]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (i) signalling events
WikiPathways Serotonin HTR1 Group and FOS Pathway
SIDS Susceptibility Pathways
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 540009(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 30).
Ref 533822Characterization of U-92016A as a selective, orally active, high intrinsic activity 5-hydroxytryptamine1A agonist. J Pharmacol Exp Ther. 1994 Nov;271(2):875-83.

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