Drug Information

Drug General Information
Drug ID
D0TV4N
Former ID
DPR000115
Drug Name
T-226296
Synonyms
LS-193063; LS-44229
Drug Type
Small molecular drug
Indication Obesity [ICD9: 278; ICD10:E66] Preclinical [536122], [538805]
Company
Takeda
Structure
Download
2D MOL

3D MOL
Formula
C26H27FN2O
InChI
InChI=1S/C26H27FN2O/c1-29(2)17-18-3-4-23-16-25(14-11-22(23)15-18)28-26(30)21-7-5-19(6-8-21)20-9-12-24(27)13-10-20/h5-14,16,18H,3-4,15,17H2,1-2H3,(H,28,30)
InChIKey
GXAQELJVODWLDD-UHFFFAOYSA-N
PubChem Compound ID
9865843
PubChem Substance ID
14830622, 24157787, 45288109, 48029661, 48179724, 49684230, 49894165, 50076295, 76275617, 103443476, 104039074, 127337954, 127337955, 134339552, 134340465, 135651224, 139348679, 172919597, 224111535, 231395513, 244230080
Target and Pathway
Target(s) Melanin-concentrating hormone receptor 1 Target Info Antagonist [536122]
KEGG Pathway Neuroactive ligand-receptor interaction
Reactome Peptide ligand-binding receptors
G alpha (q) signalling events
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 536122Emerging drugs for obesity: linking novel biological mechanisms to pharmaceutical pipelines. Expert Opin Emerg Drugs. 2005 Aug;10(3):643-60.
Ref 538805(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1314).
Ref 536122Emerging drugs for obesity: linking novel biological mechanisms to pharmaceutical pipelines. Expert Opin Emerg Drugs. 2005 Aug;10(3):643-60.

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