Drug General Information
Drug ID	D0TM0Z
Former ID	DNC008601
Drug Name	1H-indole-4,7-dione
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[529405]
Structure		Download 2D MOL 3D MOL
Formula	C8H5NO2
Canonical SMILES	C1=CC(=O)C2=C(C1=O)C=CN2
InChI	1S/C8H5NO2/c10-6-1-2-7(11)8-5(6)3-4-9-8/h1-4,9H
InChIKey	QMRIWYCCTCNABA-UHFFFAOYSA-N
PubChem Compound ID	152300
Target and Pathway
Target(s)	Indoleamine 2,3-dioxygenase	Target Info	Inhibitor	[529405]
BioCyc Pathway	Superpathway of tryptophan utilization
	Tryptophan degradation
	L-kynurenine degradation
	Tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde
	NAD de novo biosynthesis
KEGG Pathway	Tryptophan metabolism
	Metabolic pathways
	African trypanosomiasis
NetPath Pathway	TSLP Signaling Pathway
	IL5 Signaling Pathway
	TGF_beta_Receptor Signaling Pathway
PathWhiz Pathway	Tryptophan Metabolism
Reactome	Tryptophan catabolism
WikiPathways	Tryptophan metabolism
	Metabolism of amino acids and derivatives
References
Ref 529405	J Med Chem. 2008 May 8;51(9):2634-7. Epub 2008 Apr 8.Synthesis of indoleamine 2,3-dioxygenase inhibitory analogues of the sponge alkaloid exiguamine A.
Ref 529405	J Med Chem. 2008 May 8;51(9):2634-7. Epub 2008 Apr 8.Synthesis of indoleamine 2,3-dioxygenase inhibitory analogues of the sponge alkaloid exiguamine A.

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