Drug General Information
Drug ID
D0TK0W
Former ID
DIB010295
Drug Name
Ro-46-5934
Indication Alzheimer disease [ICD9: 331; ICD10:G30] Terminated [533753]
Company
F Hoffmann-La Roche Ltd
Structure
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2D MOL

3D MOL

Canonical SMILES
C(=O)(Oc1c2c([C@@H]3[C@@H](N(CC3)CCC3CCCCC3)CC2)ccc1)N(<br />C)C
CAS Number
CAS 158182-74-2
Target and Pathway
Target(s) Acetylcholinesterase Target Info Inhibitor [533753]
KEGG Pathway Glycerophospholipid metabolism
Cholinergic synapse
PANTHER Pathway Muscarinic acetylcholine receptor 1 and 3 signaling pathway
Muscarinic acetylcholine receptor 2 and 4 signaling pathway
Nicotinic acetylcholine receptor signaling pathway
Pathway Interaction Database ATF-2 transcription factor network
PathWhiz Pathway Phospholipid Biosynthesis
WikiPathways Monoamine Transport
Biogenic Amine Synthesis
Acetylcholine Synthesis
Integrated Pancreatic Cancer Pathway
References
Ref 533753A novel acetylcholinesterase inhibitor, Ro 46-5934, which interacts with muscarinic M2 receptors. Biochem Soc Trans. 1994 Aug;22(3):755-8.
Ref 533753A novel acetylcholinesterase inhibitor, Ro 46-5934, which interacts with muscarinic M2 receptors. Biochem Soc Trans. 1994 Aug;22(3):755-8.

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