Drug Information

Drug General Information
Drug ID
D0TJ7S
Former ID
DIB007040
Drug Name
PDC-41
Synonyms
THG-113; THG-113.31; PDC-31 (iv, premature labor); PGF2 alpha antagonist (primary dysmenorrhea/topical), PDC Biotech; Prostaglandin F2 alpha antagonist (primary dysmenorrhea/topical), PDC Biotech; PDC-31 (iv, premature labor), PDC; PGF2 alpha antagonist (injectable, premature labor/dysmenorrhea), PDC Biotech; Prostaglandin F2 alpha antagonist (injectable, premature labor/dysmenorrhea), PDC Biotech
Indication Dysmenorrhea [ICD9: 625.3; ICD10:N94.4-N94.6] Phase 1 [523270]
Company
Theratechnologies Inc
Target and Pathway
Target(s) Prostaglandin F2-alpha receptor Target Info Antagonist [526514]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Reactome Prostanoid ligand receptors
G alpha (q) signalling events
WikiPathways Prostaglandin Synthesis and Regulation
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Small Ligand GPCRs
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 523270ClinicalTrials.gov (NCT01250587) Dose-Finding Study of PDC31 in Patients With Primary Dysmenorrhea. U.S. National Institutes of Health.
Ref 526514THG113: a novel selective FP antagonist that delays preterm labor. Semin Perinatol. 2002 Dec;26(6):389-97.

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