Drug General Information
Drug ID	D0TH1Z
Former ID	DIB009415
Drug Name	Naxagolide
Synonyms	Dopazinol; Nazagolide; PHNO; Naxagolide hydrochloride; L-647339; MK-458; (+)-PHNO
Drug Type	Small molecular drug
Indication	Parkinson's disease [ICD9: 332; ICD10:G20]		Discontinued in Phase 2	[545272]
Company	Merck & Co Inc
Structure		Download 2D MOL 3D MOL
Formula	C15H21NO2
Canonical SMILES	[C@@H]12c3c(CC[C@H]1N(CCO2)CCC)ccc(c3)O
PubChem Compound ID	57533
Target and Pathway
Target(s)	D(2) dopamine receptor	Target Info	Modulator	[533809]
KEGG Pathway	Rap1 signaling pathway
	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	Gap junction
	Dopaminergic synapse
	Parkinson's disease
	Cocaine addiction
	Alcoholism
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Dopamine receptor mediated signaling pathway
	Nicotine pharmacodynamics pathway
Reactome	Dopamine receptors
	G alpha (i) signalling events
WikiPathways	Hypothetical Network for Drug Addiction
	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	Genes and (Common) Pathways Underlying Drug Addiction
	GPCR ligand binding
	GPCR downstream signaling
	Nicotine Activity on Dopaminergic Neurons
References
Ref 545272	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002657)
Ref 533809	Comparison between the pharmacology of dopamine receptors mediating the inhibition of cell firing in rat brain slices through the substantia nigra pars compacta and ventral tegmental area. Br J Pharmacol. 1994 Jul;112(3):873-80.

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