Drug Information

Drug General Information
Drug ID
D0T8DO
Former ID
DIB018329
Drug Name
[3H]maraviroc
Synonyms
[3H]UK 427,857; [3H]UK-427,857
Drug Type
Small molecular drug
Indication Discovery agent Investigative [542932]
Structure
Download
2D MOL
Formula
C29H41F2N5O
InChI
InChI=1S/C29H41F2N5O/c1-19(2)27-34-33-20(3)36(27)25-17-23-9-10-24(18-25)35(23)16-13-26(21-7-5-4-6-8-21)32-28(37)22-11-14-29(30,31)15-12-22/h4-8,19,22-26H,9-18H2,1-3H3,(H,32,37)/t23-,24+,25?,26-/m0/s1
InChIKey
GSNHKUDZZFZSJB-HLMSNRGBSA-N
PubChem Compound ID
3002977
PubChem Substance ID
642129, 12015618, 16284914, 24721602, 26602278, 34668114, 34939567, 46508040, 50066636, 50681186, 57410169, 92719325, 103771170, 104055495, 104179071, 111611845, 124894309, 124894310, 125085088, 126620904, 126649000, 126667024, 134337620, 134340611, 135246807, 135611105, 135650567, 135651174, 135692886, 135723692, 136340231, 137006237, 137255791, 137255792, 137434072, 143497951, 152164500, 152238539, 152258411, 152344350, 160647248, 160967811, 162201744, 162222523, 162894542, 164027255, 164339310, 164828285, 174529188, 175265823
Target and Pathway
Target(s) mRNA of CCR5 Target Info Antagonist [527876]
KEGG Pathway Cytokine-cytokine receptor interaction
Chemokine signaling pathway
Endocytosis
Toxoplasmosis
Viral carcinogenesis
NetPath Pathway TSLP Signaling Pathway
TCR Signaling Pathway
IL2 Signaling Pathway
PANTHER Pathway Inflammation mediated by chemokine and cytokine signaling pathway
Pathway Interaction Database IL12-mediated signaling events
Reactome Binding and entry of HIV virion
Chemokine receptors bind chemokines
G alpha (i) signalling events
WikiPathways TCR Signaling Pathway
GPCRs, Class A Rhodopsin-like
HIV Life Cycle
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 542932(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 803).
Ref 527876Molecular cloning and radioligand binding characterization of the chemokine receptor CCR5 from rhesus macaque and human. Biochem Pharmacol. 2005 Dec 19;71(1-2):163-72. Epub 2005 Nov 18.

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