Drug Information

Drug General Information
Drug ID
D0T6WV
Former ID
DNC012129
Drug Name
4-(2-Butyl-benzoimidazol-1-ylmethyl)-phenol
Drug Type
Small molecular drug
Indication Discovery agent Investigative [551262]
Structure
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2D MOL

3D MOL
Formula
C18H20N2O
Canonical SMILES
CCCCC1=NC2=CC=CC=C2N1CC3=CC=C(C=C3)O
InChI
1S/C18H20N2O/c1-2-3-8-18-19-16-6-4-5-7-17(16)20(18)13-14-9-11-15(21)12-10-14/h4-7,9-12,21H,2-3,8,13H2,1H3
InChIKey
SSRIUMAFZMGUFE-UHFFFAOYSA-N
PubChem Compound ID
15288898
Target and Pathway
Target(s) Type-1 angiotensin II receptor Target Info Inhibitor [551262]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Renin-angiotensin system
Renin secretion
Pathways in cancer
NetPath Pathway TGF_beta_Receptor Signaling Pathway
PANTHER Pathway Angiotensin II-stimulated signaling through G proteins and beta-arrestin
Pathway Interaction Database Arf6 trafficking events
Arf6 signaling events
Angiopoietin receptor Tie2-mediated signaling
PathWhiz Pathway Angiotensin Metabolism
Muscle/Heart Contraction
Reactome Peptide ligand-binding receptors
G alpha (q) signalling events
WikiPathways ACE Inhibitor Pathway
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Peptide GPCRs
Allograft Rejection
GPCR ligand binding
GPCR downstream signaling
References
Ref 551262Discovery and development of aryl-fused imidazole-based angiotensin II antagonists, Bioorg. Med. Chem. Lett. 4(1):213-218 (1994).
Ref 551262Discovery and development of aryl-fused imidazole-based angiotensin II antagonists, Bioorg. Med. Chem. Lett. 4(1):213-218 (1994).

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