Drug Information
Drug General Information | |||||
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Drug ID |
D0T6QX
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Former ID |
DNC004118
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Drug Name |
ZOTEPINE
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Drug Type |
Small molecular drug
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Indication | Anxiety disorder [ICD9: 300, 311; ICD10:F32, F40-F42] | Approved | [1], [2] | ||
Structure |
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Download2D MOL |
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Formula |
C18H18ClNOS
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InChI |
InChI=1S/C18H18ClNOS/c1-20(2)9-10-21-16-11-13-5-3-4-6-17(13)22-18-8-7-14(19)12-15(16)18/h3-8,11-12H,9-10H2,1-2H3
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InChIKey |
HDOZVRUNCMBHFH-UHFFFAOYSA-N
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CAS Number |
CAS 26615-21-4
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PubChem Compound ID | |||||
PubChem Substance ID |
5375173, 7848384, 7980920, 8153517, 12013422, 14899864, 29224773, 48416715, 49658668, 49832081, 49962436, 57322922, 74607145, 85174240, 85209606, 85753334, 91749410, 92729688, 103195284, 103993496, 104310109, 109613401, 114919769, 118313787, 124893805, 124893806, 125346524, 128045577, 131308055, 134341323, 134996843, 135651367, 137001502, 142405042, 144206686, 162175576, 162248926, 164829244, 170465934, 175611849, 179150247, 198951716, 224543978, 226486877, 250133641, 252157701, 252418861, 252450828
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SuperDrug ATC ID |
N05AX11
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Target and Pathway | |||||
Target(s) | 5-hydroxytryptamine 2A receptor | Target Info | Inhibitor | [3] | |
KEGG Pathway | Calcium signaling pathway | ||||
Neuroactive ligand-receptor interaction | |||||
Gap junction | |||||
Serotonergic synapse | |||||
Inflammatory mediator regulation of TRP channels | |||||
PANTHER Pathway | 5HT2 type receptor mediated signaling pathway | ||||
Reactome | Serotonin receptors | ||||
G alpha (q) signalling events | |||||
WikiPathways | Serotonin Receptor 2 and STAT3 Signaling | ||||
Serotonin Receptor 2 and ELK-SRF/GATA4 signaling | |||||
SIDS Susceptibility Pathways | |||||
Monoamine GPCRs | |||||
GPCRs, Class A Rhodopsin-like | |||||
Gastrin-CREB signalling pathway via PKC and MAPK | |||||
GPCR ligand binding | |||||
GPCR downstream signaling | |||||
GPCRs, Other | |||||
References | |||||
REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 103). | ||||
REF 2 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | ||||
REF 3 | J Med Chem. 2001 Feb 15;44(4):477-501.Current and novel approaches to the drug treatment of schizophrenia. | ||||
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