Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0T4PS
|
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| Former ID |
DIB020261
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| Drug Name |
LY 165,163
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| Synonyms |
PAPP; LY-165163
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C19H22F3N3
|
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| InChI |
InChI=1S/C19H22F3N3/c20-19(21,22)16-2-1-3-18(14-16)25-12-10-24(11-13-25)9-8-15-4-6-17(23)7-5-15/h1-7,14H,8-13,23H2
|
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| InChIKey |
GAAKALASJNGQKD-UHFFFAOYSA-N
|
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| PubChem Compound ID | |||||
| PubChem Substance ID |
795222, 6333886, 10239871, 11111756, 11413468, 15250266, 17405688, 24262978, 24278123, 26753653, 29302422, 46500433, 47589251, 47736779, 48334801, 50064554, 50107046, 50107047, 50904843, 53778238, 57339852, 85231213, 85788318, 90340652, 92303251, 103132653, 104414628, 117505147, 121361829, 123098328, 124750259, 124800165, 124881355, 124881356, 125543477, 127924210, 135076448, 135650543, 162227434, 163110011, 163565086, 178125578, 179235765, 198973003, 229944590
|
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| Target and Pathway | |||||
| Target(s) | 5-hydroxytryptamine 1A receptor | Target Info | Agonist | [2] | |
| 5-hydroxytryptamine 6 receptor | Target Info | Agonist | [3] | ||
| KEGG Pathway | cAMP signaling pathway | ||||
| Neuroactive ligand-receptor interaction | |||||
| Serotonergic synapsehsa04020:Calcium signaling pathway | |||||
| Serotonergic synapse | |||||
| PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
| 5HT1 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||||
| PathWhiz Pathway | Excitatory Neural Signalling Through 5-HTR 6 and Serotonin | ||||
| Reactome | Serotonin receptors | ||||
| G alpha (i) signalling eventsR-HSA-390666:Serotonin receptors | |||||
| G alpha (s) signalling events | |||||
| WikiPathways | Serotonin HTR1 Group and FOS Pathway | ||||
| SIDS Susceptibility Pathways | |||||
| Monoamine GPCRs | |||||
| GPCRs, Class A Rhodopsin-like | |||||
| GPCR ligand binding | |||||
| GPCR downstream signalingWP734:Serotonin Receptor 4/6/7 and NR3C Signaling | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 18). | ||||
| REF 2 | Agonist and antagonist actions of antipsychotic agents at 5-HT1A receptors: a [35S]GTPgammaS binding study. Eur J Pharmacol. 1998 Aug 21;355(2-3):245-56. | ||||
| REF 3 | Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs. Mol Pharmacol. 1993 Mar;43(3):320-7. | ||||
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