Drug Information

Drug General Information
Drug ID
D0T3LF
Former ID
DAP000572
Drug Name
Dextroamphetamine
Synonyms
Amsustain; Benzedrine; Dephadren; Desamfetamina; Dexacaps; Dexadrine; Dexamfetamina; Dexamfetamine; Dexamfetaminum; Dexamphetamine; Dexamphetaminum; Dexanfetamina; Dexedrine; Dexidrine; Isoamycin; Propisamine; Psychedrine; Raphetamine; Rhinalator; Simpatedrin; Sympamin; Sympamine; Sympatedrine; Weckamine; Desamfetamina [DCIT]; Dexedrine Spansule; Dextroamphetamine [USAN]; Dextroamphetamine resin complex; D-AM; D-Amphetamine; Dexamfetamina [INN-Spanish]; Dexamfetamine (INN); Dexamfetaminum [INN-Latin]; Dexamphetaminum [INN-Latin]; Dexanfetamina [INN-Spanish]; Dexedrine (TN); Dextro-Amphetamine; Dextro-Amphetamine Sulfate; Dextroamphetamine (USAN); Dextrostat (TN); Dl-Amphetamine; Dl-Benzedrine; Fenylo-izopropylaminyl; Beta-phenyl-isopropylamine; D-alpha-methylphenethylamine; Alpha-Methylphenethylamine, d-form; D-(S)-Amphetamine; S(+)-Amphetamine; D-(+)-Amphetamine; D-1-Phenyl-2-aminopropan; D-1-Phenyl-2-aminopropan [German]; D-1-Phenyl-2-aminopropane; D-2-Amino-1-phenylpropane; Dl-1-Phenyl-2-aminopropane; Benzeneethanamine, alpha-methyl-, (aS)-(9CI); Phenethylamine, alpha-methyl-, (+)-(8CI); (+)-(S)-Amphetamine; (+)-Amphetamine; (+)-Phenaminum; (+)-alpha-Methylphenethylamine; (+)-alpha-Methylphenylethylamine; (+/-)-Benzedrine; (+/-)-Desoxynorephedrine; (+/-)-beta-Phenylisopropylamine; (2S)-(+)-Amphetamine; (2S)-1-phenylpropan-2-amine; (S)-(+)-Amphetamine; (S)-(+)-beta-Phenylisopropylamine; (S)-1-Phenyl-2-aminopropane; (S)-1-Phenyl-2-propanamine; (S)-1-Phenyl-2-propylamine; (S)-Amphetamine; (S)-alpha-Methylphenethylamine; (S)-alpha-Phenylethylamine; (S)-alpha-methylbenzeneethanamine; (alphaS)-alpha-methylbenzeneethanamine
Drug Type
Small molecular drug
Indication Attention deficit hyperactivity disorder; Narcolepsy [ICD10:F90, G47.4] Approved [551871]
Therapeutic Class
Central Nervous System Stimulants
Company
GlaxoSmithKline
Structure
Download
2D MOL

3D MOL
Formula
C9H13N
Canonical SMILES
CC(CC1=CC=CC=C1)N
InChI
1S/C9H13N/c1-8(10)7-9-5-3-2-4-6-9/h2-6,8H,7,10H2,1H3/t8-/m0/s1
InChIKey
KWTSXDURSIMDCE-QMMMGPOBSA-N
CAS Number
CAS 51-64-9
PubChem Compound ID
5826
PubChem Substance ID
10086, 841177, 8153594, 10318924, 15170721, 17397829, 29224859, 30896359, 46506252, 47359952, 47954515, 48415867, 50004613, 50071310, 50113060, 57322985, 77830612, 96099848, 103185157, 103933285, 104310370, 127272464, 127272465, 127329738, 127329739, 127329740, 127329741, 127329742, 127329743, 127329744, 127329745, 127329746, 128273812, 128445969, 134337863, 134338391, 134338667, 134972590, 135650979, 137001216, 142361370, 160963530, 170475110, 170506196, 175266841, 175269378, 175444077, 179116645, 184585369, 223826584
ChEBI ID
ChEBI:4469
SuperDrug ATC ID
N06BA02
SuperDrug CAS ID
cas=000051649
Target and Pathway
Target(s) Trace amine-associated receptor-1 Target Info Modulator [526471], [526676], [532175], [532852]
KEGG Pathway Neuroactive ligand-receptor interaction
Reactome G alpha (s) signalling events
References
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 526471Methamphetamine increases the hippocampal alpha(2A)-adrenergic receptor and Galpha(o) in mice. Neurosci Lett. 2002 Dec 16;334(3):145-8.
Ref 526676Alpha-1B adrenergic receptor knockout mice are protected against methamphetamine toxicity. J Neurochem. 2003 Jul;86(2):413-21.
Ref 532175Involvement of the alpha(1D)-adrenergic receptor in methamphetamine-induced hyperthermia and neurotoxicity in rats. Neurotox Res. 2013 Aug;24(2):130-8.
Ref 532852Methamphetamine and HIV-1-induced neurotoxicity: role of trace amine associated receptor 1 cAMP signaling in astrocytes. Neuropharmacology. 2014 Oct;85:499-507.

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