Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0T2AD
|
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| Former ID |
DNC001284
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| Drug Name |
SB 225002
|
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
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| Formula |
C13H10BrN3O4
|
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| InChI |
InChI=1S/C13H10BrN3O4/c14-9-3-1-2-4-10(9)15-13(19)16-11-6-5-8(17(20)21)7-12(11)18/h1-7,18H,(H2,15,16,19)
|
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| InChIKey |
MQBZVUNNWUIPMK-UHFFFAOYSA-N
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| CAS Number |
CAS 131707-23-8
|
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| PubChem Compound ID | |||||
| PubChem Substance ID |
5591039, 7980570, 9993997, 14852033, 26759489, 41934772, 48110581, 49684195, 50112982, 50221429, 53788115, 53800548, 57356606, 85209285, 85787141, 97803300, 99431513, 103547644, 104082381, 106118934, 112404235, 121380087, 125333764, 125433058, 128631686, 134339365, 134340331, 134340490, 134340502, 134964511, 135293912, 135650994, 135698246, 139121540, 162023547, 163124986, 163687365, 167450927, 187071964, 196399953, 204360502, 208264769, 223427138, 223777318, 227354209, 252156740, 252457432, 252473340
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| Target and Pathway | |||||
| Target(s) | High affinity interleukin-8 receptor B | Target Info | Antagonist | [2] | |
| KEGG Pathway | Cytokine-cytokine receptor interaction | ||||
| Chemokine signaling pathway | |||||
| Endocytosis | |||||
| Epithelial cell signaling in Helicobacter pylori infection | |||||
| NetPath Pathway | TNFalpha Signaling Pathway | ||||
| PANTHER Pathway | Inflammation mediated by chemokine and cytokine signaling pathway | ||||
| Interleukin signaling pathway | |||||
| Pathway Interaction Database | IL8- and CXCR2-mediated signaling events | ||||
| Reactome | Chemokine receptors bind chemokines | ||||
| G alpha (i) signalling events | |||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | ||||
| Peptide GPCRs | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| GPCRs, Other | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 833). | ||||
| REF 2 | Interleukin-8 receptor antagonists in pulmonary diseases. Curr Opin Pharmacol. 2001 Jun;1(3):242-7. | ||||
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