Drug General Information
Drug ID	D0T1YO
Former ID	DNC011366
Drug Name	GNF-PF-2307
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[531262]
Structure		Download 2D MOL 3D MOL
Formula	C17H10N2O
Canonical SMILES	C1=CC=C(C=C1)C2=NN=C3C4=CC=CC=C4C(=O)C3=C2
InChI	1S/C17H10N2O/c20-17-13-9-5-4-8-12(13)16-14(17)10-15(18-19-16)11-6-2-1-3-7-11/h1-10H
InChIKey	ORLUBUYLVCUFDE-UHFFFAOYSA-N
PubChem Compound ID	379337
Target and Pathway
Target(s)	Type-1 angiotensin II receptor	Target Info	Inhibitor	[531262]
KEGG Pathway	Calcium signaling pathway
	cGMP-PKG signaling pathway
	Neuroactive ligand-receptor interaction
	Adrenergic signaling in cardiomyocytes
	Vascular smooth muscle contraction
	Renin-angiotensin system
	Renin secretion
	Pathways in cancer
NetPath Pathway	TGF_beta_Receptor Signaling Pathway
PANTHER Pathway	Angiotensin II-stimulated signaling through G proteins and beta-arrestin
Pathway Interaction Database	Arf6 trafficking events
	Arf6 signaling events
	Angiopoietin receptor Tie2-mediated signaling
PathWhiz Pathway	Angiotensin Metabolism
	Muscle/Heart Contraction
Reactome	Peptide ligand-binding receptors
	G alpha (q) signalling events
WikiPathways	ACE Inhibitor Pathway
	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	Peptide GPCRs
	Allograft Rejection
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 531262	Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. Epub 2010 Oct 21.In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2).
Ref 531262	Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. Epub 2010 Oct 21.In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2).

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