TTD | Drug: D0T0PN

Drug General Information
Drug ID	D0T0PN
Former ID	DNC000470
Drug Name	CP-122721
Drug Type	Small molecular drug
Indication	Major depressive disorder [ICD9: 296.2, 296.3, 710.0; ICD10:F32, F33, M32]		Phase 2	[546318]
Structure		Download 2D MOL 3D MOL
Formula	C20H23F3N2O2
Canonical SMILES	COC1=C(C=C(C=C1)OC(F)(F)F)CNC2CCCNC2C3=CC=CC=C3
InChI	1S/C20H23F3N2O2/c1-26-18-10-9-16(27-20(21,22)23)12-15(18)13-25-17-8-5-11-24-19(17)14-6-3-2-4-7-14/h2-4,6-7,9-10,12,17,19,24-25H,5,8,11,13H2,1H3/t17-,19-/m0/s1
InChIKey	ZIWFCOIGUNPHPM-HKUYNNGSSA-N
CAS Number	CAS 145742-28-5
PubChem Compound ID	9821217
PubChem Substance ID	14780102, 14902445, 24124685, 44857177, 78634444, 103309381, 103962360, 124954232, 129909114, 137034189, 140143344, 144210525, 198985924, 226520674, 241036480
Target and Pathway
Target(s)	Substance-P receptor	Target Info	Antagonist	[536307]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Measles
PANTHER Pathway	CCKR signaling map ST
Reactome	G alpha (q) signalling events
WikiPathways	SIDS Susceptibility Pathways
	Gastrin-CREB signalling pathway via PKC and MAPK
	Spinal Cord Injury
	Peptide GPCRs
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 546318	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007429)
Ref 536307	A review of drug options in age-related macular degeneration therapy and potential new agents. Expert Opin Pharmacother. 2006 Dec;7(17):2355-68.

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Drug Information