Drug Information
Drug General Information | |||||
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Drug ID |
D0SP2J
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Former ID |
DIB019034
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Drug Name |
bufotenine
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Synonyms |
DM5-HT; dimethylserotonin; N,N-dimethyl-5-HT; N,N-dimethylserotonin; 5-OH-DMT
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Drug Type |
Small molecular drug
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Indication | Discovery agent | Investigative | [538916] | ||
Structure |
Download2D MOL |
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Formula |
C12H16N2O
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InChI |
InChI=1S/C12H16N2O/c1-14(2)6-5-9-8-13-12-4-3-10(15)7-11(9)12/h3-4,7-8,13,15H,5-6H2,1-2H3
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InChIKey |
VTTONGPRPXSUTJ-UHFFFAOYSA-N
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PubChem Compound ID | |||||
PubChem Substance ID |
10497, 396834, 595001, 6308314, 8157399, 10523919, 12015261, 14822340, 29228776, 46507174, 46530531, 47440788, 47589506, 47885916, 49984707, 50413991, 57326082, 58005029, 85209815, 94524805, 103172929, 103934497, 104322802, 124954092, 126579212, 126736670, 129525791, 131727789, 134973156, 135584581, 135650030, 137002805, 144206443, 160964711, 162159006, 162955505, 164807342, 179226198, 184585265, 198955790, 203093598, 206256315, 226830471, 249924472
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Target and Pathway | |||||
Target(s) | 5-hydroxytryptamine 1D receptor | Target Info | Antagonist | [534292] | |
5-hydroxytryptamine 2A receptor | Target Info | Antagonist | [534136] | ||
5-hydroxytryptamine 6 receptor | Target Info | Antagonist | [534430] | ||
5-hydroxytryptamine 7 receptor | Target Info | Agonist | [534022] | ||
5-hydroxytryptamine 5A receptor | Target Info | Antagonist | [534080] | ||
KEGG Pathway | cAMP signaling pathway | ||||
Neuroactive ligand-receptor interaction | |||||
Serotonergic synapsehsa04020:Calcium signaling pathway | |||||
Gap junction | |||||
Serotonergic synapse | |||||
Inflammatory mediator regulation of TRP channelshsa04020:Calcium signaling pathway | |||||
Serotonergic synapsehsa04014:Ras signaling pathway | |||||
Calcium signaling pathway | |||||
PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
5HT1 type receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||||
WikiPathways | Serotonin HTR1 Group and FOS Pathway | ||||
Monoamine GPCRs | |||||
GPCRs, Class A Rhodopsin-like | |||||
GPCR ligand binding | |||||
GPCR downstream signalingWP733:Serotonin Receptor 2 and STAT3 Signaling | |||||
Serotonin Receptor 2 and ELK-SRF/GATA4 signaling | |||||
SIDS Susceptibility Pathways | |||||
Gastrin-CREB signalling pathway via PKC and MAPK | |||||
GPCR downstream signaling | |||||
GPCRs, OtherWP734:Serotonin Receptor 4/6/7 and NR3C Signaling | |||||
GPCR downstream signalingWP734:Serotonin Receptor 4/6/7 and NR3C Signaling | |||||
GPCRs, OtherWP58:Monoamine GPCRs | |||||
References | |||||
Ref 534022 | Molecular cloning of a mammalian serotonin receptor that activates adenylate cyclase. Mol Pharmacol. 1993 Aug;44(2):229-36. | ||||
Ref 534080 | Expression of functional mouse 5-HT5A serotonin receptor in the methylotrophic yeast Pichia pastoris: pharmacological characterization and localization. FEBS Lett. 1995 Dec 27;377(3):451-6. | ||||
Ref 534136 | Mapping the binding site pocket of the serotonin 5-Hydroxytryptamine2A receptor. Ser3.36(159) provides a second interaction site for the protonated amine of serotonin but not of lysergic acid diethylamide or bufotenin. J Biol Chem. 1996 Jun 21;271(25):14672-5. | ||||
Ref 534292 | Alniditan, a new 5-hydroxytryptamine1D agonist and migraine-abortive agent: ligand-binding properties of human 5-hydroxytryptamine1D alpha, human 5-hydroxytryptamine1D beta, and calf 5-hydroxytryptamine1D receptors investigated with [3H]5-hydroxytryptamine and [3H]alniditan. Mol Pharmacol. 1996 Dec;50(6):1567-80. | ||||
Ref 534430 | Functional and radioligand binding characterization of rat 5-HT6 receptors stably expressed in HEK293 cells. Neuropharmacology. 1997 Apr-May;36(4-5):713-20. |
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