Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0SN7I
|
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| Former ID |
DCL000387
|
||||
| Drug Name |
SB-656933
|
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| Drug Type |
Small molecular drug
|
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| Indication | Cystic fibrosis; Chronic obstructive pulmonary disease [ICD9: 277.0, 490-492, 494-496; ICD10:E84, J40-J44, J47] | Phase 2 | [1], [2] | ||
| Company |
GlaxoSmithKline
|
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| Structure |
|
Download2D MOL |
|||
| Formula |
C17H17Cl2FN4O4S
|
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| InChI |
InChI=1S/C17H17Cl2FN4O4S/c18-10-4-5-13(23-17(26)22-12-3-1-2-11(20)14(12)19)15(25)16(10)29(27,28)24-8-6-21-7-9-24/h1-5,21,25H,6-9H2,(H2,22,23,26)
|
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| InChIKey |
YQYFEGTYCUQBEI-UHFFFAOYSA-N
|
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | High affinity interleukin-8 receptor B | Target Info | Antagonist | [3] | |
| KEGG Pathway | Cytokine-cytokine receptor interaction | ||||
| Chemokine signaling pathway | |||||
| Endocytosis | |||||
| Epithelial cell signaling in Helicobacter pylori infection | |||||
| NetPath Pathway | TNFalpha Signaling Pathway | ||||
| PANTHER Pathway | Inflammation mediated by chemokine and cytokine signaling pathway | ||||
| Interleukin signaling pathway | |||||
| Pathway Interaction Database | IL8- and CXCR2-mediated signaling events | ||||
| Reactome | Chemokine receptors bind chemokines | ||||
| G alpha (i) signalling events | |||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | ||||
| Peptide GPCRs | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| GPCRs, Other | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8499). | ||||
| REF 2 | Clinical pipeline report, company report or official report of GlaxoSmithKline. | ||||
| REF 3 | Clinical pipeline report, company report or official report of GlaxoSmithKline (2009). | ||||
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