Drug Information

Drug General Information
Drug ID
D0SG0N
Former ID
DIB000694
Drug Name
DB-200
Synonyms
DB-200; DB-200 series (topical, psoriasis); CPT-1 inhibitor (topical, psoriasis), DARA; DB-200 series (topical, psoriasis), DARA BioSciences
Indication Psoriasis [ICD9: 696; ICD10:L40] Terminated [548567]
Company
DARA BioSciences
Target and Pathway
Target(s) Carnitine O-palmitoyltransferase I Target Info Inhibitor [533757]
KEGG Pathway Fatty acid degradation
Fatty acid metabolism
PPAR signaling pathway
AMPK signaling pathway
Adipocytokine signaling pathway
Glucagon signaling pathway
PathWhiz Pathway Fatty acid Metabolism
Reactome RORA activates gene expression
PPARA activates gene expression
Import of palmitoyl-CoA into the mitochondrial matrix
WikiPathways SIDS Susceptibility Pathways
Mitochondrial LC-Fatty Acid Beta-Oxidation
Nuclear Receptors Meta-Pathway
PPAR Alpha Pathway
Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Circadian Clock
Fatty Acid Beta Oxidation
AMPK Signaling
References
Ref 548567Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800026687)
Ref 533757Comparison of the effects of carnitine palmitoyltransferase-1 and -2 inhibitors on rat heart hypertrophy. Cardioscience. 1994 Sep;5(3):193-7.

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