Drug Information

Drug General Information
Drug ID
D0S9SD
Former ID
DAP001084
Drug Name
Emtricitabine
Synonyms
Coviracil; DOTFC; Emtriva; RCV; Racivir; BW 1592; BW 524W91; BW524W91; Atripla (TN); BW-524W91; Coviracil (TN); Coviracil(TM); DRG-0208; Emtriva (TN); Emtriva(TM); Truvada (TN); Emtricitabine (JAN/USAN/INN); Beta-L-2',3'-dideoxy-5-fluoro-3'-thiacytidine; Beta-L-(-)-(2R,5S)-5-Fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine; (-)-(2R,5S)-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine; (-)-.beta.-L-FTC; (-)-2',3'-Dideoxy-5-fluoro-3'-thiacytidine; (-)-2'-Deoxy-5-fluoro-3'-thiacytidine; (-)-FTC; (-)-beta-2',3'-dideoxy-5-fluoro-3'-thiacytidine; (-)-cis-4-amino-5-fluoro-1-(2-hydroxymethyl-1,3-oxathiolan-5-yl)-(1H)-pyrimidin-2-one; (2R-cis)-4-Amino-5-fluoro-1-(2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-2(1H)-pyrimidinone; 1-(2-(Hydroxymethyl)oxathiolan-5-yl)-5-fluorocytosine; 2',3',5-FTC; 2',3'-Dideoxy-5-fluoro-3'-thiacytidine; 2'-Deoxy-5-fluoro-3'-oxa-4'-thiocytidine; 2'-Deoxy-5-fluoro-3'-thiacytidine; 2-FTC; 3'-Thia-2'.3'-dideoxy-5-fluorocytidine; 4-Amino-5-fluoro-1-[(2R,5S)-(hydroxymethyl)-1,3-oxathiolan-5-yl]-2(1H)-pyrimidinone; 4-amino-5-fluoro-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidin-2(1H)-one; 4-amino-5-fluoro-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidin-2-one; 5-Fluoro-1-((2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl)cytosine; 5-Fluoro-1-(2-(hydroxymethyl)-1,3-oxathiolan-5-yl)cytosine; 5-fluoro-1-[(2R,5S)-2-(hydroxymethyl)[1,3]oxathiolan-5-yl]cytosine; 524W91; FTC
Drug Type
Small molecular drug
Indication Hepatitis virus infection; Human immunodeficiency virus infection [ICD9: 573.3, 279.3; ICD10:K75.9, B20-B26] Approved [527650], [532210], [536361]
HBV infection [ICD9: 070.2-070.3; ICD10:B16, B18.0, B18.1] Phase 3 [550812]
Therapeutic Class
Anti-HIV Agents
Company
Gilead; Bristol-Myers Squibb
Structure
Download
2D MOL

3D MOL
Formula
C8H10FN3O3S
Canonical SMILES
C1C(OC(S1)CO)N2C=C(C(=NC2=O)N)F
InChI
1S/C8H10FN3O3S/c9-4-1-12(8(14)11-7(4)10)5-3-16-6(2-13)15-5/h1,5-6,13H,2-3H2,(H2,10,11,14)/t5-,6+/m0/s1
InChIKey
XQSPYNMVSIKCOC-NTSWFWBYSA-N
CAS Number
CAS 143491-57-0
PubChem Compound ID
60877
PubChem Substance ID
582989, 600446, 7848262, 8187110, 11528728, 12014747, 14749730, 14847619, 24875080, 26757984, 43118210, 46507606, 48424313, 49830960, 50064421, 57314168, 71814561, 76230216, 92308841, 92729801, 99313695, 103232542, 104178758, 104321867, 117506117, 118046007, 118313743, 126592961, 126653602, 126654249, 126665394, 127310207, 127310208, 129727356, 134223773, 134338341, 135018286, 135022892, 135590997, 136947986, 137006539, 142372786, 144205746, 151992517, 152034369, 160826182, 160964220, 162792750, 163388307, 163621100
SuperDrug ATC ID
J05AF09
SuperDrug CAS ID
cas=143491570
Drug Resistance Mutation (DRM)
DRM DRM Info
Target and Pathway
Target(s) HIV reverse transcriptase Target Info Modulator [527650], [532210]
References
Ref 527650Emtricitabine: a novel nucleoside reverse transcriptase inhibitor. Drugs Today (Barc). 2005 Apr;41(4):241-52.
Ref 532210Nat Rev Drug Discov. 2013 Feb;12(2):87-90.
Ref 536361Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20.
Ref 550812Clinical pipeline report, company report or official report of Gilead (2011).
Ref 527650Emtricitabine: a novel nucleoside reverse transcriptase inhibitor. Drugs Today (Barc). 2005 Apr;41(4):241-52.
Ref 532210Nat Rev Drug Discov. 2013 Feb;12(2):87-90.

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