Drug Information

Drug General Information
Drug ID
D0S6BX
Former ID
DIB020737
Drug Name
PL017
Synonyms
3-N-Me-Phe-morphiceptin; PL-017; PL 017
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539035]
Structure
Download
2D MOL
Formula
C29H37N5O5
InChI
InChI=1S/C29H37N5O5/c1-32(25(18-19-7-3-2-4-8-19)29(39)33-15-5-9-23(33)26(31)36)28(38)24-10-6-16-34(24)27(37)22(30)17-20-11-13-21(35)14-12-20/h2-4,7-8,11-14,22-25,35H,5-6,9-10,15-18,30H2,1H3,(H2,31,36)/t22-,23+,24-,25-/m0/s1
InChIKey
JAKBYSTWCHUQOK-NDBXHCKUSA-N
PubChem Compound ID
115335
PubChem Substance ID
7980345, 10236744, 14787776, 29296837, 47437907, 57339125, 76141422, 103204256, 103827693, 104030442, 104398156, 135072139, 135650836, 184587907, 196376598
Target and Pathway
Target(s) Mu-type opioid receptor Target Info Agonist [533547]
KEGG Pathway Neuroactive ligand-receptor interaction
Estrogen signaling pathway
Morphine addiction
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Enkephalin release
Pathway Interaction Database IL4-mediated signaling events
Reactome Peptide ligand-binding receptors
G alpha (i) signalling events
WikiPathways TCR Signaling Pathway
GPCRs, Class A Rhodopsin-like
Peptide GPCRs
Opioid Signalling
GPCR ligand binding
GPCR downstream signaling
References
Ref 539035(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1671).
Ref 533547Potent morphiceptin analogs: structure activity relationships and morphine-like activities. J Pharmacol Exp Ther. 1983 Nov;227(2):403-8.

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