Drug General Information
Drug ID
D0S4SX
Former ID
DNCL001837
Drug Name
K-134
Drug Type
Small molecular drug
Indication Arteriosclerosis [ICD9: 440; ICD10:I70] Phase 2 [522473]
Company
Kowa Pharmaceuticals America
Structure
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2D MOL

3D MOL

Formula
C8H11NO5S
Canonical SMILES
CC1(C(N2C(S1(=O)=O)CC2=O)C(=O)O)C
InChI
1S/C8H11NO5S/c1-8(2)6(7(11)12)9-4(10)3-5(9)15(8,13)14/h5-6H,3H2,1-2H3,(H,11,12)/t5-,6+/m1/s1
InChIKey
FKENQMMABCRJMK-RITPCOANSA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Phosphodiesterase (PDE) 3 Target Info Modulator [531714], [544269]
References
Ref 522473ClinicalTrials.gov (NCT00783081) Safety and Efficacy of K-134 for the Treatment of Intermittent Claudication. U.S. National Institutes of Health.
Ref 531714A phase II dose-ranging study of the phosphodiesterase inhibitor K-134 in patients with peripheral artery disease and claudication. J Vasc Surg. 2012 Feb;55(2):381-389.e1.
Ref 544269K-134, a Phosphodiesterase 3 Inhibitor, Prevents Brain Damage by Inhibiting Thrombus Formation in a Rat Cerebral Infarction Model. PLoS One. 2012; 7(10): e46432.

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