Drug General Information
Drug ID
D0S0HA
Former ID
DIB015019
Drug Name
O6-Benzylguanine alkylade
Synonyms
KRX-0402; O6-Benzylguanine; O6-Benzylguanine (BG)
Indication Sarcoma [ICD9: 202.8; ICD10:C81-C86] Phase 3 [527774], [529958]
Company
Wiley-Liss; Keryx Biopharmaceuticals
Structure
Download
2D MOL

3D MOL

Canonical SMILES
Nc1nc(OCc2ccccc2)c3nc[nH]c3n1
InChI
1S/C12H11N5O/c13-12-16-10-9(14-7-15-10)11(17-12)18-6-8-4-2-1-3-5-8/h1-5,7H,6H2,(H3,13,14,15,16,17)
InChIKey
KRWMERLEINMZFT-UHFFFAOYSA-N
Target and Pathway
Target(s) Methylated-DNA--protein-cysteine methyltransferase Target Info Modulator [527774], [529958]
WikiPathways DNA Damage Reversal
References
Ref 527774Phase I trial of temozolomide plus O6-benzylguanine for patients with recurrent or progressive malignant glioma. J Clin Oncol. 2005 Oct 1;23(28):7178-87.
Ref 529958Phase II trial of temozolomide plus o6-benzylguanine in adults with recurrent, temozolomide-resistant malignant glioma. J Clin Oncol. 2009 Mar 10;27(8):1262-7.
Ref 527774Phase I trial of temozolomide plus O6-benzylguanine for patients with recurrent or progressive malignant glioma. J Clin Oncol. 2005 Oct 1;23(28):7178-87.
Ref 529958Phase II trial of temozolomide plus o6-benzylguanine in adults with recurrent, temozolomide-resistant malignant glioma. J Clin Oncol. 2009 Mar 10;27(8):1262-7.

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