Drug General Information
Drug ID	D0RI7T
Former ID	DNC008631
Drug Name	1-(1-(Biphenyl-4-yl)allyl)-1H-imidazole
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[529625]
Structure		Download 2D MOL 3D MOL
Formula	C18H16N2
Canonical SMILES	C=CC(C1=CC=C(C=C1)C2=CC=CC=C2)N3C=CN=C3
InChI	1S/C18H16N2/c1-2-18(20-13-12-19-14-20)17-10-8-16(9-11-17)15-6-4-3-5-7-15/h2-14,18H,1H2
InChIKey	VEPBIHWDSCDYJS-UHFFFAOYSA-N
PubChem Compound ID	44586827
Target and Pathway
Target(s)	17 alpha-hydroxylase-C17, 20-lyase	Target Info	Inhibitor	[529625]
BioCyc Pathway	Superpathway of steroid hormone biosynthesis
	Glucocorticoid biosynthesis
	Androgen biosynthesis
KEGG Pathway	Steroid hormone biosynthesis
	Metabolic pathways
	Ovarian steroidogenesis
	Prolactin signaling pathway
PathWhiz Pathway	Androgen and Estrogen Metabolism
	Steroidogenesis
Reactome	Androgen biosynthesis
	Glucocorticoid biosynthesis
	Endogenous sterols
WikiPathways	Metapathway biotransformation
	Steroid Biosynthesis
	Oxidation by Cytochrome P450
	Metabolism of steroid hormones and vitamin D
	Glucocorticoid & Mineralcorticoid Metabolism
	Prostate Cancer
	Phase 1 - Functionalization of compounds
References
Ref 529625	Bioorg Med Chem. 2008 Aug 15;16(16):7715-27. Epub 2008 Jul 9.Synthesis, biological evaluation, and molecular modeling studies of methylene imidazole substituted biaryls as inhibitors of human 17alpha-hydroxylase-17,20-lyase (CYP17)--part II: Core rigidification and influence of substituents at the methylene bridge.
Ref 529625	Bioorg Med Chem. 2008 Aug 15;16(16):7715-27. Epub 2008 Jul 9.Synthesis, biological evaluation, and molecular modeling studies of methylene imidazole substituted biaryls as inhibitors of human 17alpha-hydroxylase-17,20-lyase (CYP17)--part II: Core rigidification and influence of substituents at the methylene bridge.

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