Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0RF7O
|
||||
| Former ID |
DIB020376
|
||||
| Drug Name |
ML347
|
||||
| Synonyms |
ML-347
|
||||
| Drug Type |
Small molecular drug
|
||||
| Indication | Discovery agent | Investigative | [532338] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C22H16N4O
|
||||
| InChI |
InChI=1S/C22H16N4O/c1-27-17-9-7-15(8-10-17)16-12-24-22-20(13-25-26(22)14-16)18-4-2-6-21-19(18)5-3-11-23-21/h2-14H,1H3
|
||||
| InChIKey |
FVRYPYDPKSZGNS-UHFFFAOYSA-N
|
||||
| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | activin A receptor, type I | Target Info | Inhibitor | [532338] | |
| Bone morphogenetic protein receptor | Target Info | Inhibitor | [532338] | ||
| Activin receptor-like kinase-1 | Target Info | Inhibitor | [532338] | ||
| PANTHER Pathway | TGF-beta signaling pathway | ||||
| Pathway Interaction Database | ALK1 pathway | ||||
| ALK1 signaling events | |||||
| WikiPathways | Endochondral Ossification | ||||
| Ectoderm Differentiation | |||||
| Mesodermal Commitment Pathway | |||||
| Endoderm Differentiation | |||||
| Hair Follicle Development: Cytodifferentiation (Part 3 of 3) | |||||
| Hair Follicle Development: Induction (Part 1 of 3) | |||||
| Signaling by BMP | |||||
| Integrated Breast Cancer Pathway | |||||
| Heart Development | |||||
| BMP Signalling and Regulation | |||||
| References | |||||
| Ref 532338 | Synthesis and structure-activity relationships of a novel and selective bone morphogenetic protein receptor (BMP) inhibitor derived from the pyrazolo[1.5-a]pyrimidine scaffold of dorsomorphin: the discovery of ML347 as an ALK2 versus ALK3 selective MLPCN probe. Bioorg Med Chem Lett. 2013 Jun 1;23(11):3248-52. | ||||
| Ref 532338 | Synthesis and structure-activity relationships of a novel and selective bone morphogenetic protein receptor (BMP) inhibitor derived from the pyrazolo[1.5-a]pyrimidine scaffold of dorsomorphin: the discovery of ML347 as an ALK2 versus ALK3 selective MLPCN probe. Bioorg Med Chem Lett. 2013 Jun 1;23(11):3248-52. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.