Drug General Information
Drug ID
D0R9ZB
Former ID
DAP000327
Drug Name
Propiomazine
Synonyms
Phenoctyl; Propiomazina; Propiomazinum; Propionylpromethazine; Dorevan (TN); Dorevane (TN); Indorm (TN); Largon (TN); Propavan (TN); Propiomazina [INN-Spanish]; Propiomazinum [INN-Latin]; Serentin (TN); Wy-1359; Propiomazine (USAN/INN); Propiomazine [USAN:BAN:INN]; Propiomazine [USAN:INN:BAN]; 1-(10-(2-(Dimethylamino)propyl)phenothiazin-2-yl)-1-propanone; 1-[10-[2-(dimethylamino)propyl]phenothiazin-2-yl]propan-1-one; 1-{10-[2-(dimethylamino)propyl]-10H-phenothiazin-2-yl}propan-1-one; 10-(2-Dimethylaminopropyl)-2-propionylphenothiazine; 10-Dimethylaminoisopropyl-2-propionylphenothiazine; 2-Propionyl-10-(2-(dimethylamino)propyl)phenothiazine; 3-Propionyl-10-dimethylaminoisopropylphenothiazine
Drug Type
Small molecular drug
Indication Insomnia; Anxiety disorder [ICD9: 307.41, 307.42, 327.0, 780.51, 780.52, 300, 311; ICD10:F51.0, G47.0, F32, F40-F42] Approved [538458], [542304], [551871]
Therapeutic Class
Sedatives and Hypnotics
Company
Hikma Maple Ltd
Structure
Download
2D MOL

3D MOL

Formula
C20H24N2OS
InChI
InChI=1S/C20H24N2OS/c1-5-18(23)15-10-11-20-17(12-15)22(13-14(2)21(3)4)16-8-6-7-9-19(16)24-20/h6-12,14H,5,13H2,1-4H3
InChIKey
UVOIBTBFPOZKGP-UHFFFAOYSA-N
CAS Number
CAS 362-29-8
PubChem Compound ID
PubChem Substance ID
ChEBI ID
ChEBI:8491
SuperDrug ATC ID
N05CM06
SuperDrug CAS ID
cas=000362298
Target and Pathway
Target(s) Histamine H1 receptor Target Info Antagonist [536316]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
PANTHER Pathway Histamine H1 receptor mediated signaling pathway
Reactome Histamine receptors
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
IL-4 Signaling Pathway
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 538458FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 012382.
Ref 542304(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7284).
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 536316How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

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