Drug Information

Drug General Information
Drug ID
D0R9OH
Former ID
DAP001239
Drug Name
Sulfamethoxazole
Synonyms
Bactrimel; Gamazole; Gantanol; Metoxal; Radonil; SMX; Septran; Simsinomin; Sinomin; Solfametossazolo; Sulfamethalazole; Sulfamethoxazol; Sulfamethoxazolum; Sulfamethoxizole; Sulfamethylisoxazole; Sulfametoxazol; Sulfisomezole; Sulphamethalazole; Sulphamethoxazol; Sulphamethoxazole; Sulphamethylisoxazole; Sulphisomezole; Trib; Urobak; Solfametossazolo [DCIT]; Sulfamethoxazole sodium; MS 53; Sulphamethoxazole BP 98; ALBB-002089; Apo-Sulfamethoxazole; Azo-gantanol; Bactrim (TN); Gantanol-DS; Ro 4-2130; Septra (TN); Septrin (TN); Sulfamethoxazolum [INN-Latin]; Sulfametoxazol [INN-Spanish]; Sulpha-methoxizole; Ro 6-2580/11; Ro-4-2130; Sulfamethoxazole [USAN:INN:JAN]; TMP/SMX (MIXTURE)); Sulfamethoxazole (JP15/USP/INN); N1-(5-Methyl-3-isoxazolyl)sulfanilamide; N1-(5-Methylisoxazol-3-yl)sulfanilamide; SULFAMETHOXAZOLE (8064-90-2 (TRIMETHOPRIM/SULFAMETHOXAZOLE); N'-(5-Methyl-3-isoxazole)sulfanilamide; N'-(5-Methyl-3-isoxazolyl)sulfanilamide; N'-(5-Methylisoxazol-3-yl)sulphanilamide; N(sup 1)-(5-Methyl-3-isoxazolyl)sulfanilamide; N(sup 1)-(5-Methyl-3-isoxazolyl)sulphanilamide; N(sup1)-(5-Methyl-3-isoxazolyl)sulfanilamide; Sulfanilamide, N1-(5-methyl-3-isoxazolyl)-(8CI); 3-(p-Aminophenylsulfonamido)-5-methylisoxazole; 3-(para-Aminophenylsulphonamido)-5-methylisoxazole; 3-Sulfanilamido-5-methylisoxazole; 3-Sulphanilamido-5-methylisoxazole; 4-Amino-N-(5-methyl-3-isoxazolyl)benzenesulfonamide; 4-Amino-N-(5-methyl-isoxazol-3-yl)-benzenesulfonamide; 4-Amino-N-[5-methyl-3-isoxazolyl]benzenesulfonamide; 4-amino-N-(5-methyl-1,2-oxazol-3-yl)benzenesulfonamide; 4-amino-N-(5-methylisoxazol-3-yl)benzenesulfonamide; 5-Methyl-3-sulfanilamidoisoxazole; 5-Methyl-3-sulfanylamidoisoxazole; 5-Methyl-3-sulphanil-amidoisoxazole
Drug Type
Small molecular drug
Indication Bacterial infections [ICD9: 001-009, 010-018, 020-027, 030-041, 080-088, 090-099, 100-104; ICD10:A00-B99] Approved [536773], [551871]
Therapeutic Class
Antiinfective Agents
Structure
Download
2D MOL

3D MOL
Formula
C10H11N3O3S
Canonical SMILES
CC1=CC(=NO1)NS(=O)(=O)C2=CC=C(C=C2)N
InChI
1S/C10H11N3O3S/c1-7-6-10(12-16-7)13-17(14,15)9-4-2-8(11)3-5-9/h2-6H,11H2,1H3,(H,12,13)
InChIKey
JLKIGFTWXXRPMT-UHFFFAOYSA-N
CAS Number
CAS 723-46-6
PubChem Compound ID
5329
PubChem Substance ID
9523, 430150, 602530, 855654, 3160889, 4484561, 7847513, 7980702, 8149537, 8153272, 10321458, 10533933, 10589657, 11112438, 11335824, 11361063, 11363888, 11366450, 11369012, 11371628, 11373888, 11377174, 11385461, 11462035, 11466205, 11467325, 11484632, 11485730, 11488604, 11490400, 11492160, 11494808, 14718462, 14798729, 17388720, 24870521, 24899752, 25623303, 26611929, 26679802, 26746946, 26746947, 29224383, 46508111, 47188230, 47216775, 47291127, 47365185, 47440251, 47662281
ChEBI ID
ChEBI:9332
SuperDrug ATC ID
J01EC01
SuperDrug CAS ID
cas=000723466
Drug Resistance Mutation (DRM)
DRM DRM Info
Target and Pathway
Target(s) Dihydropteroate synthetase Target Info Inhibitor [537865]
References
Ref 536773How many modes of action should an antibiotic have? Curr Opin Pharmacol. 2008 Oct;8(5):564-73. Epub 2008 Jul 30.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 537865In vitro activities of novel antifolate drug combinations against Plasmodium falciparum and human granulocyte CFUs. Antimicrob Agents Chemother. 1995 Apr;39(4):948-52.

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