Drug Information

Drug General Information
Drug ID
D0R1FZ
Former ID
DIB020258
Drug Name
LXA4
Synonyms
5,6,15-triHETE ; lipoxin A4
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538629]
Structure
Download
2D MOL
Formula
C20H32O5
InChI
InChI=1S/C20H32O5/c1-2-3-8-12-17(21)13-9-6-4-5-7-10-14-18(22)19(23)15-11-16-20(24)25/h4-7,9-10,13-14,17-19,21-23H,2-3,8,11-12,15-16H2,1H3,(H,24,25)/b6-4-,7-5+,13-9+,14-10+/t17-,18+,19-/m0/s1
InChIKey
IXAQOQZEOGMIQS-SSQFXEBMSA-N
PubChem Compound ID
5280914
PubChem Substance ID
8550, 4266097, 8616440, 14717862, 14900949, 14925511, 24896257, 26754801, 26754802, 39289895, 47439991, 48110204, 50110782, 57357927, 76715551, 79177356, 92309794, 99300708, 99302226, 103543153, 104046428, 113854224, 126525082, 135308855, 135651504, 137006644, 140337479, 162227012, 164758015, 179205550, 241153138, 252455518, 252467993
Target and Pathway
Target(s) FMLP-related receptor I Target Info Agonist [530641]
GPR32 Target Info Agonist [530641]
FPR3 Target Info Agonist [534386]
Pathway Interaction Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
Reactome G alpha (q) signalling events
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 538629(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1034).
Ref 530641Resolvin D1 binds human phagocytes with evidence for proresolving receptors. Proc Natl Acad Sci U S A. 2010 Jan 26;107(4):1660-5.
Ref 534386Aspirin-triggered 15-epi-lipoxin A4 (LXA4) and LXA4 stable analogues are potent inhibitors of acute inflammation: evidence for anti-inflammatory receptors. J Exp Med. 1997 May 5;185(9):1693-704.

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