Drug General Information |
Drug ID |
D0R0YW
|
Former ID |
DIB003945
|
Drug Name |
HM-5016504
|
Synonyms |
HMPL-504; C-Met inhibitor (cancer), Hutchison
|
Indication |
Cancer [ICD9: 140-229; ICD10:C00-C96]
|
Phase 2 |
[1]
|
Company |
Hutchison Medipharma Enterprises Ltd
|
Target and Pathway |
Target(s) |
Hepatocyte growth factor receptor |
Target Info |
Inhibitor |
[2]
|
KEGG Pathway
|
Ras signaling pathway
|
Rap1 signaling pathway
|
Cytokine-cytokine receptor interaction
|
Endocytosis
|
PI3K-Akt signaling pathway
|
Axon guidance
|
Focal adhesion
|
Adherens junction
|
Bacterial invasion of epithelial cells
|
Epithelial cell signaling in Helicobacter pylori infection
|
Malaria
|
Pathways in cancer
|
Transcriptional misregulation in cancer
|
Proteoglycans in cancer
|
MicroRNAs in cancer
|
Renal cell carcinoma
|
Melanoma
|
Central carbon metabolism in cancer
|
Pathway Interaction Database
|
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
|
Arf6 signaling events
|
Signaling events mediated by TCPTP
|
Posttranslational regulation of adherens junction stability and dissassembly
|
Direct p53 effectors
|
Syndecan-1-mediated signaling events
|
Stabilization and expansion of the E-cadherin adherens junction
|
a6b1 and a6b4 Integrin signaling
|
FGF signaling pathway
|
Regulation of retinoblastoma protein
|
Reactome
|
Sema4D mediated inhibition of cell attachment and migration
|
WikiPathways
|
TGF beta Signaling Pathway
|
Signaling of Hepatocyte Growth Factor Receptor
|
Focal Adhesion
|
Extracellular vesicle-mediated signaling in recipient cells
|
Signaling Pathways in Glioblastoma
|
miR-targeted genes in squamous cell - TarBase
|
miR-targeted genes in muscle cell - TarBase
|
miR-targeted genes in lymphocytes - TarBase
|
miR-targeted genes in epithelium - TarBase
|
Semaphorin interactions
|
References |
REF 1 | ClinicalTrials.gov (NCT02127710) A Phase II Trial to Evaluate the Efficacy of AZD6094 (HMPL-504) in Patients With Papillary Renal Cell Carcinoma (PRCC). U.S. National Institutes of Health. |
---|
REF 2 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1815). |