| Drug General Information |
| Drug ID |
D0QO8X
|
| Former ID |
DNC012793
|
| Drug Name |
1,2,3,4-Tetrahydro-isoquinolin-7-ol
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C9H11NO
|
| Canonical SMILES |
C1CNCC2=C1C=CC(=C2)O
|
| InChI |
1S/C9H11NO/c11-9-2-1-7-3-4-10-6-8(7)5-9/h1-2,5,10-11H,3-4,6H2
|
| InChIKey |
RADQTHXRZJGDQI-UHFFFAOYSA-N
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| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Alpha-2A adrenergic receptor |
Target Info |
Inhibitor |
[1]
|
|---|
| Alpha-2B adrenergic receptor |
Target Info |
Inhibitor |
[1]
|
| Alpha-2C adrenergic receptor |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
|
cGMP-PKG signaling pathway
|
|
Neuroactive ligand-receptor interactionhsa04022:cGMP-PKG signaling pathway
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Neuroactive ligand-receptor interaction
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PANTHER Pathway
|
Alpha adrenergic receptor signaling pathwayP00002:Alpha adrenergic receptor signaling pathway
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Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP00002:Alpha adrenergic receptor signaling pathway
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Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
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Reactome
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Adrenoceptors
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Adrenaline signalling through Alpha-2 adrenergic receptor
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Adrenaline,noradrenaline inhibits insulin secretion
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G alpha (i) signalling events
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G alpha (z) signalling events
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Surfactant metabolismR-HSA-390696:Adrenoceptors
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G alpha (z) signalling eventsR-HSA-390696:Adrenoceptors
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Surfactant metabolism
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WikiPathways
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Monoamine GPCRs
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GPCRs, Class A Rhodopsin-like
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Platelet Aggregation (Plug Formation)
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Integration of energy metabolism
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GPCR ligand binding
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GPCR downstream signalingWP58:Monoamine GPCRs
|
|
GPCR downstream signaling
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| References |
| REF 1 | J Med Chem. 1997 Dec 5;40(25):3997-4005.Examination of the role of the acidic hydrogen in imparting selectivity of 7-(aminosulfonyl)-1,2,3,4-tetrahydroisoquinoline (SK&F 29661) toward inhibition of phenylethanolamine N-methyltransferase vs the alpha 2-adrenoceptor. |
|---|
