TTD | Drug: D0Q9UO

Drug General Information
Drug ID	D0Q9UO
Former ID	DNC000714
Drug Name	GW-311616
Drug Type	Small molecular drug
Indication	Discovery agent		Discontinued in Phase 1	[546572]
Structure		Download 2D MOL 3D MOL
Formula	C24H29N3O5
Canonical SMILES	CC1=C(C2=CC=CC=C2N1)CCNCC3=CC=C(C=C3)C=CC(=O)NO.CC(C(=O<br />)O)O
InChI	1S/C21H23N3O2.C3H6O3/c1-15-18(19-4-2-3-5-20(19)23-15)12-13-22-14-17-8-6-16(7-9-17)10-11-21(25)24-26;1-2(4)3(5)6/h2-11,22-23,26H,12-14H2,1H3,(H,24,25);2,4H,1H3,(H,5,6)/b11-10+;/t;2-/m.1/s1
InChIKey	XVDWNSFFSMWXJJ-BDRHRQAXSA-N
PubChem Compound ID	24775955
PubChem Substance ID	49698112, 56182321, 134340073, 198969832
Target and Pathway
Target(s)	Leukocyte elastase	Target Info	Inhibitor	[535494]
KEGG Pathway	Transcriptional misregulation in cancer
KEGG Pathway	Systemic lupus erythematosus
Pathway Interaction Database	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
Pathway Interaction Database	C-MYB transcription factor network
Reactome	Collagen degradation
	Degradation of the extracellular matrix
	Activation of Matrix Metalloproteinases
WikiPathways	Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
	Human Complement System
	Degradation of collagen
References
Ref 546572	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800008997)
Ref 535494	Neutrophil elastase inhibitors as treatment for COPD. Expert Opin Investig Drugs. 2002 Jul;11(7):965-80.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.

Drug Information