| Drug General Information |
| Drug ID |
D0Q7QU
|
| Former ID |
DNC003851
|
| Drug Name |
Alpha-Hydroxy-Midazolam
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C18H13ClFN3O
|
| Canonical SMILES |
C1C2=CN=C(N2C3=C(C=C(C=C3)Cl)C(=N1)C4=CC=CC=C4F)CO
|
| InChI |
1S/C18H13ClFN3O/c19-11-5-6-16-14(7-11)18(13-3-1-2-4-15(13)20)22-9-12-8-21-17(10-24)23(12)16/h1-8,24H,9-10H2
|
| InChIKey |
QHSMEGADRFZVNE-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Cytochrome P450 3A4 |
Target Info |
Inhibitor |
[1]
|
|---|
|
KEGG Pathway
|
Steroid hormone biosynthesis
|
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Linoleic acid metabolism
|
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Retinol metabolism
|
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Metabolism of xenobiotics by cytochrome P450
|
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Drug metabolism - cytochrome P450
|
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Drug metabolism - other enzymes
|
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Metabolic pathways
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Bile secretion
|
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Chemical carcinogenesis
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PathWhiz Pathway
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Caffeine Metabolism
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Retinol Metabolism
|
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Reactome
|
Xenobiotics
|
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Aflatoxin activation and detoxification
|
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WikiPathways
|
Metapathway biotransformation
|
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Aflatoxin B1 metabolism
|
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Estrogen metabolism
|
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Benzo(a)pyrene metabolism
|
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Tamoxifen metabolism
|
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Tryptophan metabolism
|
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Oxidation by Cytochrome P450
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Nuclear Receptors in Lipid Metabolism and Toxicity
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Nuclear Receptors Meta-Pathway
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Farnesoid X Receptor Pathway
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Vitamin D Receptor Pathway
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Felbamate Metabolism
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Lidocaine metabolism
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Nifedipine Activity
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Colchicine Metabolic Pathway
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Irinotecan Pathway
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Drug Induction of Bile Acid Pathway
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Fatty Acid Omega Oxidation
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Codeine and Morphine Metabolism
|
| References |
| REF 1 | Bioorg Med Chem Lett. 2003 Nov 3;13(21):3643-5.Design and synthesis of a new fluorescent probe for cytochrome P450 3A4 (CYP 3A4). |
|---|
